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Cancers 2010, 2(2), 989-999; doi:10.3390/cancers2020989
Review

Prognostic Significance of Melanoma Differentiation and Trans-Differentiation

 and *
Received: 2 March 2010; in revised form: 13 April 2010 / Accepted: 18 May 2010 / Published: 26 May 2010
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Abstract: Cutaneous malignant melanomas share a number of molecular attributes such as limitless replicative potential that define capabilities acquired by most malignancies. Accordingly, much effort has been focused on evaluating and validating protein markers related to these capabilities to function as melanoma prognostic markers. However, a few studies have also highlighted the prognostic value of markers that define melanocytic differentiation and the plasticity of melanoma cells to trans-differentiate along several other cellular pathways. Here, we provide a comprehensive review and evaluation of the prognostic significance of melanocyte-lineage markers such as MITF and melanogenic proteins, as well as markers of vascular epithelial and neuronal differentiation.
Keywords: melanoma; melanocyte; prognostic markers; differentiation; trans-differentiation melanoma; melanocyte; prognostic markers; differentiation; trans-differentiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Maddodi, N.; Setaluri, V. Prognostic Significance of Melanoma Differentiation and Trans-Differentiation. Cancers 2010, 2, 989-999.

AMA Style

Maddodi N, Setaluri V. Prognostic Significance of Melanoma Differentiation and Trans-Differentiation. Cancers. 2010; 2(2):989-999.

Chicago/Turabian Style

Maddodi, Nityanand; Setaluri, Vijayasaradhi. 2010. "Prognostic Significance of Melanoma Differentiation and Trans-Differentiation." Cancers 2, no. 2: 989-999.



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