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Cancers 2010, 2(2), 989-999; doi:10.3390/cancers2020989

Prognostic Significance of Melanoma Differentiation and Trans-Differentiation

Department of Dermatology, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, B25, Madison WI 53706, USA
* Author to whom correspondence should be addressed.
Received: 2 March 2010 / Revised: 13 April 2010 / Accepted: 18 May 2010 / Published: 26 May 2010
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Cutaneous malignant melanomas share a number of molecular attributes such as limitless replicative potential that define capabilities acquired by most malignancies. Accordingly, much effort has been focused on evaluating and validating protein markers related to these capabilities to function as melanoma prognostic markers. However, a few studies have also highlighted the prognostic value of markers that define melanocytic differentiation and the plasticity of melanoma cells to trans-differentiate along several other cellular pathways. Here, we provide a comprehensive review and evaluation of the prognostic significance of melanocyte-lineage markers such as MITF and melanogenic proteins, as well as markers of vascular epithelial and neuronal differentiation.
Keywords: melanoma; melanocyte; prognostic markers; differentiation; trans-differentiation melanoma; melanocyte; prognostic markers; differentiation; trans-differentiation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Maddodi, N.; Setaluri, V. Prognostic Significance of Melanoma Differentiation and Trans-Differentiation. Cancers 2010, 2, 989-999.

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