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Cancers 2010, 2(1), 43-50; doi:10.3390/cancers20100043

Regional Therapy for Recurrent Metastatic Melanoma Confined to the Extremity: Hyperthermic Isolated Limb Perfusion vs. Isolated Limb Infusion

1
Cutaneous Oncology Program, Lakeland Regional Cancer Center, Lakeland, FL 33804-1057, USA
2
Department of Surgery, Morton Plant Mease, North Bay Hospital, New Port Richey, FL 34652, USA
3
Moffitt Cancer Center, Tampa, FL 33612, USA
*
Author to whom correspondence should be addressed.
Received: 14 January 2010 / Revised: 9 February 2010 / Accepted: 9 February 2010 / Published: 10 February 2010
(This article belongs to the Special Issue Current Concepts in the Diagnosis and Treatment of Cutaneous Melanoma)
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Abstract

Melanoma patients with recurrent disease confined to an extremity can be offered one of two regional therapies that both give high complete response rates. Isolated limb infusion (ILI) is a newer technique performed with catheters and tourniquets that has a reduced potential morbidity, decreased efficacy and does not treat the regional nodal basin. Hyperthermic Isolated Limb Perfusion (HILP) is an open surgical technique that includes removal of the regional nodal basin as part of the surgical procedure. An analysis was performed of the rates of regional nodal disease in this patient population to determine the percentage of patients with stage III metastatic disease to the lymph nodes that would be under treated with the ILI technique. A total of 229 patients underwent a HILP for melanoma with regional lymph node dissection as is our standard between July 1987 and December 2009. Ninty-two of the 229 patients (40%) had metastatic regional nodal disease documented at the time of the HILP procedure. HILP is the only technique that addresses all micrometastatic disease on the extremity.
Keywords: metastatic melanoma; extremity; hyperthermia; isolated limb perfusion metastatic melanoma; extremity; hyperthermia; isolated limb perfusion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Reintgen, M.; Reintgen, C.; Nobo, C.; Giuliano, R.; Shivers, S.; Reintgen, D. Regional Therapy for Recurrent Metastatic Melanoma Confined to the Extremity: Hyperthermic Isolated Limb Perfusion vs. Isolated Limb Infusion. Cancers 2010, 2, 43-50.

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