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Cancers 2010, 2(1), 32-42; doi:10.3390/cancers2010032

Oxidative Stress and Exhaled Breath Analysis: A Promising Tool for Detection of Lung Cancer

Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia
Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW 2031, Australia
Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW 2031, Australia
Author to whom correspondence should be addressed.
Received: 10 December 2009 / Revised: 29 January 2010 / Accepted: 1 February 2010 / Published: 8 February 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
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Lung cancer is one of the few neoplasia in which the principal aetiology is known, with cigarette smoke donating a considerable oxidative burden to the lungs. This may be part of the aetiology of lung cancer, but the neoplastic process is also associated with increased oxidative stress. Nonetheless, it is difficult to study the mechanisms behind the induction of lung cancer in smokers, but newer techniques of breath analysis targeting markers of oxidative stress and anti-oxidant capacity show promise in unravelling some of the pathways. This review highlights recent developments in the assessment of oxidative stress by non-invasive methods of breath analysis which are becoming powerful research techniques with possible clinical applications.
Keywords: exhaled breath analysis; lung cancer; oxidative stress exhaled breath analysis; lung cancer; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chan, H.P.; Lewis, C.; Thomas, P.S. Oxidative Stress and Exhaled Breath Analysis: A Promising Tool for Detection of Lung Cancer. Cancers 2010, 2, 32-42.

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