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Oxidative Stress and Exhaled Breath Analysis: A Promising Tool for Detection of Lung Cancer
Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia
Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW 2031, Australia
Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW 2031, Australia
* Author to whom correspondence should be addressed.
Received: 10 December 2009; in revised form: 29 January 2010 / Accepted: 1 February 2010 / Published: 8 February 2010
Abstract: Lung cancer is one of the few neoplasia in which the principal aetiology is known, with cigarette smoke donating a considerable oxidative burden to the lungs. This may be part of the aetiology of lung cancer, but the neoplastic process is also associated with increased oxidative stress. Nonetheless, it is difficult to study the mechanisms behind the induction of lung cancer in smokers, but newer techniques of breath analysis targeting markers of oxidative stress and anti-oxidant capacity show promise in unravelling some of the pathways. This review highlights recent developments in the assessment of oxidative stress by non-invasive methods of breath analysis which are becoming powerful research techniques with possible clinical applications.
Keywords: exhaled breath analysis; lung cancer; oxidative stress
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Cite This Article
MDPI and ACS Style
Chan, H.P.; Lewis, C.; Thomas, P.S. Oxidative Stress and Exhaled Breath Analysis: A Promising Tool for Detection of Lung Cancer. Cancers 2010, 2, 32-42.
Chan HP, Lewis C, Thomas PS. Oxidative Stress and Exhaled Breath Analysis: A Promising Tool for Detection of Lung Cancer. Cancers. 2010; 2(1):32-42.
Chan, Hiang Ping; Lewis, Craig; Thomas, Paul S. 2010. "Oxidative Stress and Exhaled Breath Analysis: A Promising Tool for Detection of Lung Cancer." Cancers 2, no. 1: 32-42.