Table of Contents
Cancers, Volume 10, Issue 3 (March 2018)
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Cover Story (view full-size image) Endoplasmic reticulum (ER) is a crucial organelle that is responsible for several fundamental [...] Read more. Endoplasmic reticulum (ER) is a crucial organelle that is responsible for several fundamental cellular activities. Disturbances to ER homeostasis leads to the accumulation of unfolded/aggregated proteins, which in turn leads to unfolded protein response (UPR). Controlling induced UPR via ER stress could be an attractive molecular target in cancer therapies. Tannic acid (TA, a naturally occurring polyphenol) is a commonly used compound as a food, drink, and pharmaceutical additive. Herein, we demonstrated the holistic mechanism of TA in annihilating prostate cancer cell growth, clonogenic, invasive, and migratory potential of prostate cancer cells. This study corroborates that TA promotes ER stress-mediated cancer cell death.