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Micromachines 2017, 8(8), 246; doi:10.3390/mi8080246

Universal Micromachining Platform and Basic Technologies for the Manufacture and Marking of Microphysiological Systems

1
Institute of Manufacturing Technology, Technische Universität Dresden, George-Baehr-Str.1, 01069 Dresden, Germany
2
Fraunhofer Institute for Material and Beam Technology IWS, Winterbergstrasse 28, 01277 Dresden, Germany
3
Kunststofftechnik Paderborn, Universität Paderborn University, Warburger Straße 100, 33098 Paderborn, Germany
*
Author to whom correspondence should be addressed.
Received: 30 May 2017 / Revised: 17 July 2017 / Accepted: 3 August 2017 / Published: 11 August 2017
(This article belongs to the Special Issue Additive Manufacturing for Medical Applications)
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Abstract

Micro Physiological Systems (MPS), also known as Multi-Organ-Chip, Organ-on-a-Chip, or Body-on-a-Chip, are advanced microfluidic systems that allow the cultivation of different types of cells and tissue in just one common circuit. Furthermore, they thus can also adjust the interaction of these different tissues. Perspectival MPS will replace animal testing. For fast and flexible manufacturing and marking of MPS, a concept for a universal micromachining platform has been developed which provides the following latest key technologies: laser micro cutting of polymer foils, laser micro- and sub-micro-structuring of polymer foils, 3D printing of polymer components as well as optical inspection and online process control. The combination of different laser sources, processing optics, inspection systems, and print heads on multiple axes allows the change and exactly positioning to the workpiece during the process. Therewith, the realization of MPS including 3D printed components as well as direct laser interference patterned surfaces for well-defined cell adhesion and product protection is possible. Additional basic technologies for the generation of periodical line-like structures at polycarbonate foils using special Direct Laser Interference Patterning (DLIP) optics as well as for the 3D printing of fluid-tight cell culture reservoirs made of Acrylonitrile Butadiene Styrene directly onto polycarbonate microfluidics were established. A first prototype of the universal micromachining platform combining different lasers with Direct Laser Writing and DLIP is shown. With this laser micro cutting as well as laser micro-structuring of polycarbonate (PC) foils and therewith functionalization for MPS application could be successfully demonstrated. View Full-Text
Keywords: microfluidic; lab-on-a-chip; 3D printing; direct laser writing; direct laser interference patterning microfluidic; lab-on-a-chip; 3D printing; direct laser writing; direct laser interference patterning
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Günther, K.; Sonntag, F.; Moritzer, E.; Hirsch, A.; Klotzbach, U.; Lasagni, A.F. Universal Micromachining Platform and Basic Technologies for the Manufacture and Marking of Microphysiological Systems. Micromachines 2017, 8, 246.

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