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Micromachines 2017, 8(3), 67; doi:10.3390/mi8030067

Fabrication of All Glass Bifurcation Microfluidic Chip for Blood Plasma Separation

1
School of Mechanical Engineering, Chung-Ang University, Seoul 06974, Korea
2
School of Mechanical Engineering, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do 38541, Korea
*
Authors to whom correspondence should be addressed.
Academic Editors: Weihua Li, Hengdong Xi and Say Hwa Tan
Received: 12 December 2016 / Revised: 9 February 2017 / Accepted: 20 February 2017 / Published: 24 February 2017
(This article belongs to the Special Issue Insights and Advancements in Microfluidics)
View Full-Text   |   Download PDF [5400 KB, uploaded 28 February 2017]   |  

Abstract

An all-glass bifurcation microfluidic chip for blood plasma separation was fabricated by a cost-effective glass molding process using an amorphous carbon (AC) mold, which in turn was fabricated by the carbonization of a replicated furan precursor. To compensate for the shrinkage during AC mold fabrication, an enlarged photoresist pattern master was designed, and an AC mold with a dimensional error of 2.9% was achieved; the dimensional error of the master pattern was 1.6%. In the glass molding process, a glass microchannel plate with negligible shape errors (~1.5%) compared to AC mold was replicated. Finally, an all-glass bifurcation microfluidic chip was realized by micro drilling and thermal fusion bonding processes. A separation efficiency of 74% was obtained using the fabricated all-glass bifurcation microfluidic chip. View Full-Text
Keywords: glass molding; amorphous carbon mold; microfluidics; blood plasma separation; bifurcation microfluidic chip glass molding; amorphous carbon mold; microfluidics; blood plasma separation; bifurcation microfluidic chip
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jang, H.; Haq, M.R.; Ju, J.; Kim, Y.; Kim, S.-M.; Lim, J. Fabrication of All Glass Bifurcation Microfluidic Chip for Blood Plasma Separation. Micromachines 2017, 8, 67.

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