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Micromachines 2017, 8(3), 73; doi:10.3390/mi8030073

High-Throughput Particle Manipulation Based on Hydrodynamic Effects in Microchannels

1
and
2,3,*
1
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, Beijing 100190, China
2
State Key Laboratory of Nonlinear Mechanics, Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China
3
School of Engineering Science, University of Chinese Academy of Sciences, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Academic Editors: Weihua Li, Hengdong Xi and Say Hwa Tan
Received: 14 January 2017 / Accepted: 23 February 2017 / Published: 1 March 2017
(This article belongs to the Special Issue Insights and Advancements in Microfluidics)
View Full-Text   |   Download PDF [7127 KB, uploaded 3 March 2017]   |  

Abstract

Microfluidic techniques are effective tools for precise manipulation of particles and cells, whose enrichment and separation is crucial for a wide range of applications in biology, medicine, and chemistry. Recently, lateral particle migration induced by the intrinsic hydrodynamic effects in microchannels, such as inertia and elasticity, has shown its promise for high-throughput and label-free particle manipulation. The particle migration can be engineered to realize the controllable focusing and separation of particles based on a difference in size. The widespread use of inertial and viscoelastic microfluidics depends on the understanding of hydrodynamic effects on particle motion. This review will summarize the progress in the fundamental mechanisms and key applications of inertial and viscoelastic particle manipulation. View Full-Text
Keywords: particle manipulation; inertial lift; viscoelastic effects; microfluidics; lab on a chip; high throughput particle manipulation; inertial lift; viscoelastic effects; microfluidics; lab on a chip; high throughput
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Liu, C.; Hu, G. High-Throughput Particle Manipulation Based on Hydrodynamic Effects in Microchannels. Micromachines 2017, 8, 73.

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