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Micromachines 2017, 8(10), 291; https://doi.org/10.3390/mi8100291

A Method to Encapsulate Small Organic Molecules in Calcium Phosphate Nanoparticles Based on the Supramolecular Chemistry of Cyclodextrin

1,†
,
2,†
,
3,* , 4
,
4
and
1,*
1
Pulmonary Department, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
2
Department of respiration, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
3
Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang 236000, China
4
School of Biological and Medical Engineering, Hefei University of Technology, Hefei 230009, China
These authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 3 September 2017 / Revised: 19 September 2017 / Accepted: 19 September 2017 / Published: 27 September 2017
(This article belongs to the Special Issue Biomedical Applications of Nanotechnology and Nanomaterials)
View Full-Text   |   Download PDF [4252 KB, uploaded 27 September 2017]   |  

Abstract

Calcium phosphate nanoparticles (CPNPs) encapsulating small organic molecules, such as imaging agents and drugs, are considered to be ideal devices for cancer diagnosis or therapy. However, it is generally difficult to encapsulate small organic molecules in CPNPs because of the lack of solubility in water or binding affinity to calcium phosphate. To solve these issues, we utilized the carboxymethyl β-cyclodextrin (CM-β-CD) to increase the solubility and binding affinity to small organic molecules for the encapsulation into CPNPs in this work. The results indicated that the model molecules, hydrophilic rhodamine B (RB) and hydrophobic docetaxel (Dtxl), are successfully encapsulated into CPNPs with the assistance of CM-β-CD. We also demonstrated the CPNPs could be remarkably internalized into A549 cells, resulting in the efficient inhibition of tumor cells’ growth. View Full-Text
Keywords: calcium phosphate nanoparticles; supramolecular chemistry; cyclodextrin; small organic drug delivery calcium phosphate nanoparticles; supramolecular chemistry; cyclodextrin; small organic drug delivery
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Zhu, Z.; Li, F.; Zhong, F.; Zhai, K.; Tao, W.; Sun, G. A Method to Encapsulate Small Organic Molecules in Calcium Phosphate Nanoparticles Based on the Supramolecular Chemistry of Cyclodextrin. Micromachines 2017, 8, 291.

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