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Micromachines 2016, 7(9), 153; doi:10.3390/mi7090153

Integration of an Optical Ring Resonator Biosensor into a Self-Contained Microfluidic Cartridge with Active, Single-Shot Micropumps

1
Fraunhofer Institute for Electronic Nanosystems (ENAS), Technologie-Campus 3, 09126 Chemnitz, Germany
2
DAS Photonics S.L., Valencia 46022, Spain
3
Centro de Astrobiología (INTA-CSIC), Torrejon de Ardoz 28850, Spain
4
Evoleo Technologies Lda, 442565 Maia, Portugal
5
BiFlow Systems GmbH, 09126 Chemnitz, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Jeong-Bong Lee
Received: 4 August 2016 / Revised: 24 August 2016 / Accepted: 29 August 2016 / Published: 13 September 2016
(This article belongs to the Collection Lab-on-a-Chip)
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Abstract

While there have been huge advances in the field of biosensors during the last decade, their integration into a microfluidic environment avoiding external tubing and pumping is still neglected. Herein, we show a new microfluidic design that integrates multiple reservoirs for reagent storage and single-use electrochemical pumps for time-controlled delivery of the liquids. The cartridge has been tested and validated with a silicon nitride-based photonic biosensor incorporating multiple optical ring resonators as sensing elements and an immunoassay as a potential target application. Based on experimental results obtained with a demonstration model, subcomponents were designed and existing protocols were adapted. The newly-designed microfluidic cartridges and photonic sensors were separately characterized on a technical basis and performed well. Afterwards, the sensor was functionalized for a protein detection. The microfluidic cartridge was loaded with the necessary assay reagents. The integrated pumps were programmed to drive the single process steps of an immunoassay. The prototype worked selectively, but only with a low sensitivity. Further work must be carried out to optimize biofunctionalization of the optical ring resonators and to have a more suitable flow velocity progression to enhance the system’s reproducibility. View Full-Text
Keywords: microfluidics; biosensor; optical ring resonator; micropumps; lab-on-a-chip microfluidics; biosensor; optical ring resonator; micropumps; lab-on-a-chip
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Geidel, S.; Peransi Llopis, S.; Rodrigo, M.; de Diego-Castilla, G.; Sousa, A.; Nestler, J.; Otto, T.; Gessner, T.; Parro, V. Integration of an Optical Ring Resonator Biosensor into a Self-Contained Microfluidic Cartridge with Active, Single-Shot Micropumps. Micromachines 2016, 7, 153.

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