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Micromachines 2016, 7(4), 63; doi:10.3390/mi7040063

A One-Square-Millimeter Compact Hollow Structure for Microfluidic Pumping on an All-Glass Chip

Department of Biology, School of Life Sciences, Xiamen University, Xiamen 361005, China
Academic Editor: Rolf Wuthrich
Received: 22 February 2016 / Revised: 4 April 2016 / Accepted: 5 April 2016 / Published: 9 April 2016
(This article belongs to the Special Issue Glass Micromachining)
View Full-Text   |   Download PDF [5837 KB, uploaded 9 April 2016]   |  

Abstract

A micro surface tension pump is a new type of low-cost, built-in, all-glass, microfluidic pump on a glass microchip fabricated by one-step glass etching. However, geometric minimization and optimization for practical use are challenging. Here, we report a one-square-millimeter, built-in, all-glass pump controlled by two-way digital gas pressure. The pump consists simply of two joint chambers and a piston between two gas control channels. It does not require pre-perfusion for initialization, and can immediately begin to run when a liquid enters its inlet channel. It is also more reliable than conventional micro pumps for practical use due to its ability to restart after the formation of a blocking bubble, which can serve as a valuable troubleshooting procedure. Its volumetric pump output was 0.5–0.7 nL·s−1 under a pump head pressure of 300 Pa. View Full-Text
Keywords: lab-on-a-chip; all-glass; microfluidic; on-chip valve and pump; surface tension; glass microchip lab-on-a-chip; all-glass; microfluidic; on-chip valve and pump; surface tension; glass microchip
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Peng, X.Y.L. A One-Square-Millimeter Compact Hollow Structure for Microfluidic Pumping on an All-Glass Chip. Micromachines 2016, 7, 63.

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