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Micromachines 2016, 7(2), 32; doi:10.3390/mi7020032

Challenges and Opportunities of Centrifugal Microfluidics for Extreme Point-of-Care Testing

1
Department of Biomedical Engineering, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), 100 Banyeon-ri, Eonyang-eup, Ulju-gun, Ulsan 689-798, Korea
2
Center for Soft and Living Matter, Institute for Basic Science (IBS), UNIST-gil 50, Ulsan 689-798, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Marc Madou
Received: 2 December 2015 / Revised: 21 January 2016 / Accepted: 14 February 2016 / Published: 19 February 2016
(This article belongs to the Special Issue Centrifugal (Compact-Disc) Microfluidics for Extreme POC)
View Full-Text   |   Download PDF [923 KB, uploaded 19 February 2016]   |  

Abstract

The advantages offered by centrifugal microfluidic systems have encouraged its rapid adaptation in the fields of in vitro diagnostics, clinical chemistry, immunoassays, and nucleic acid tests. Centrifugal microfluidic devices are currently used in both clinical and point-of-care settings. Recent studies have shown that this new diagnostic platform could be potentially used in extreme point-of-care settings like remote villages in the Indian subcontinent and in Africa. Several technological inventions have decentralized diagnostics in developing countries; however, very few microfluidic technologies have been successful in meeting the demand. By identifying the finest difference between the point-of-care testing and extreme point-of-care infrastructure, this review captures the evolving diagnostic needs of developing countries paired with infrastructural challenges with technological hurdles to healthcare delivery in extreme point-of-care settings. In particular, the requirements for making centrifugal diagnostic devices viable in developing countries are discussed based on a detailed analysis of the demands in different clinical settings including the distinctive needs of extreme point-of-care settings. View Full-Text
Keywords: diagnostics; centrifugal microfluidics; point-of-care; developing countries; clinical chemistry; immunoassays; nucleic acid tests diagnostics; centrifugal microfluidics; point-of-care; developing countries; clinical chemistry; immunoassays; nucleic acid tests
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Michael, I.J.; Kim, T.-H.; Sunkara, V.; Cho, Y.-K. Challenges and Opportunities of Centrifugal Microfluidics for Extreme Point-of-Care Testing. Micromachines 2016, 7, 32.

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