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Micromachines 2016, 7(10), 185; doi:10.3390/mi7100185

Review of Microfluidic Photobioreactor Technology for Metabolic Engineering and Synthetic Biology of Cyanobacteria and Microalgae

Department of Electrical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan
Current address: Max Planck Institute for terrestrial Microbiology, Karl-von-Frisch-Str. 16, D-35043 Marburg, Germany
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Author to whom correspondence should be addressed.
Academic Editors: Nam-Trung Nguyen and Seyed Ali Mousavi Shaegh
Received: 27 April 2016 / Revised: 16 August 2016 / Accepted: 16 August 2016 / Published: 11 October 2016
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Abstract

One goal of metabolic engineering and synthetic biology for cyanobacteria and microalgae is to engineer strains that can optimally produce biofuels and commodity chemicals. However, the current workflow is slow and labor intensive with respect to assembly of genetic parts and characterization of production yields because of the slow growth rates of these organisms. Here, we review recent progress in the microfluidic photobioreactors and identify opportunities and unmet needs in metabolic engineering and synthetic biology. Because of the unprecedented experimental resolution down to the single cell level, long-term real-time monitoring capability, and high throughput with low cost, microfluidic photobioreactor technology will be an indispensible tool to speed up the development process, advance fundamental knowledge, and realize the full potential of metabolic engineering and synthetic biology for cyanobacteria and microalgae. View Full-Text
Keywords: cyanobacteria; photobioreactor; photosynthesis; synthetic biology; metabolic engineering; microfluidics; optofluidics; photobiology; bioreactor cyanobacteria; photobioreactor; photosynthesis; synthetic biology; metabolic engineering; microfluidics; optofluidics; photobiology; bioreactor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yang, Y.-T.; Wang, C.Y. Review of Microfluidic Photobioreactor Technology for Metabolic Engineering and Synthetic Biology of Cyanobacteria and Microalgae. Micromachines 2016, 7, 185.

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