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Micromachines 2015, 6(5), 648-659; doi:10.3390/mi6050648

On-Chip Transportation and Measurement of Mechanical Characteristics of Oocytes in an Open Environment

Department of Mechanical Science and Engineering, Nagoya University, Furo-Cho, Chikusa-Ku, Nagoya 464-8601, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Jeong-Bong Lee
Received: 21 April 2015 / Revised: 11 May 2015 / Accepted: 19 May 2015 / Published: 22 May 2015
(This article belongs to the Collection Lab-on-a-Chip)
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Abstract

We propose a system that transports oocytes and measures their mechanical characteristics in an open environment using a robot integrated microfluidic chip (chip). The cells are transported through a micropillar array in the chip, and their characteristics are measured by a mechanical probe and a force sensor. Because the chip has an open microchannel, important cells such as oocytes are easily introduced and collected without the risk for losing them. In addition, any bubbles trapped in the chip, which degrade the measurement precision, are easily removed. To transport the oocytes through the open microchannel, we adopt a transportation technique based on a vibration-induced flow. Under this flow, oocytes arrive at the measurement point, where their mechanical characteristics are determined. We demonstrate the introduction, transportation, measurement of mechanical characteristics, and collection of oocytes using this system. View Full-Text
Keywords: cell mechanical characteristics; cell manipulation; open-chip; oocyte; robot cell mechanical characteristics; cell manipulation; open-chip; oocyte; robot
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nakahara, K.; Sakuma, S.; Hayakawa, T.; Arai, F. On-Chip Transportation and Measurement of Mechanical Characteristics of Oocytes in an Open Environment. Micromachines 2015, 6, 648-659.

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