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Micromachines 2015, 6(12), 1923-1934; doi:10.3390/mi6121465

A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research

1
Microsystems Laboratory, École Polytechnique Fédérale de Lausanne, EPFL-STI-IMT-LMIS4, Station 17, Lausanne 1015, Switzerland
2
Department of Biomedical Engineering, National Cheng Kung University, Tainan 70101, Taiwan
3
Medical Device Innovation Center, National Cheng Kung University, Tainan 70101, Taiwan
4
Brain Mind Institute and School of Life Sciences, École Polytechnique Fédérale de Lausanne, EPFL-SV-BMI-CMSN, Station 15, Lausanne 1015, Switzerland
5
Qwane Biosciences SA, Lausanne 1015, Switzerland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Andreas Richter
Received: 27 October 2015 / Revised: 18 November 2015 / Accepted: 1 December 2015 / Published: 7 December 2015
(This article belongs to the Special Issue Polymeric Microsystems)
View Full-Text   |   Download PDF [2622 KB, uploaded 21 December 2015]   |  

Abstract

Polydimethylsiloxane (PDMS) and SU-8 are currently two very commonly used polymeric materials in the microfluidics field for biological applications. However; there is a pressing need to find a simple, reliable, irreversible bonding method between these two materials for their combined use in innovative integrated microsystems. In this paper, we attempt to investigate the aminosilane-mediated irreversible bonding method for PDMS and SU-8 with X-Ray Photoelectron Spectroscopy (XPS) surface analysis and bonding strength tests. Additionally, the selected bonding method was applied in fabricating a microelectrode array (MEA) device, including microfluidic features, which allows electrophysiological observations on compartmentalized neuronal cultures. As there is a growing trend towards microfluidic devices for neuroscience research, this type of integrated microdevice, which can observe functional alterations on compartmentalized neuronal culture, can potentially be used for neurodegenerative disease research and pharmaceutical development. View Full-Text
Keywords: PDMS; SU-8; bonding technology; surface silanization; XPS analysis; tensile strength test; integrated microfluidic-MEA device; compartmentalized neural cell culture; neural activity recording PDMS; SU-8; bonding technology; surface silanization; XPS analysis; tensile strength test; integrated microfluidic-MEA device; compartmentalized neural cell culture; neural activity recording
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ren, Y.; Huang, S.-H.; Mosser, S.; Heuschkel, M.O.; Bertsch, A.; Fraering, P.C.; Chen, J.-J.J.; Renaud, P. A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research. Micromachines 2015, 6, 1923-1934.

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