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Micromachines 2015, 6(1), 121-135; doi:10.3390/mi6010121

A Rapid and Low-Cost Nonlithographic Method to Fabricate Biomedical Microdevices for Blood Flow Analysis

1
School of Technology and Management (ESTiG), Polytechnic Institute of Bragança (IPB), Campus de Santa Apolónia, 5300-253 Bragança, Portugal
2
Transport Phenomena Research Center, Department of Chemical Engineering, Engineering Faculty, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
3
Laboratory of Catalysis and Materials—Associate Laboratory LSRE/LCM, Engineering Faculty, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
4
Department of Mechanical Engineering, Minho University, Campus de Azurém, 4800-058 Guimarães, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Cheng Luo
Received: 27 October 2014 / Accepted: 16 December 2014 / Published: 30 December 2014
(This article belongs to the Special Issue Micro/Nano Fabrication)
View Full-Text   |   Download PDF [3081 KB, uploaded 30 December 2014]   |  

Abstract

Microfluidic devices are electrical/mechanical systems that offer the ability to work with minimal sample volumes, short reactions times, and have the possibility to perform massive parallel operations. An important application of microfluidics is blood rheology in microdevices, which has played a key role in recent developments of lab-on-chip devices for blood sampling and analysis. The most popular and traditional method to fabricate these types of devices is the polydimethylsiloxane (PDMS) soft lithography technique, which requires molds, usually produced by photolithography. Although the research results are extremely encouraging, the high costs and time involved in the production of molds by photolithography is currently slowing down the development cycle of these types of devices. Here we present a simple, rapid, and low-cost nonlithographic technique to create microfluidic systems for biomedical applications. The results demonstrate the ability of the proposed method to perform cell free layer (CFL) measurements and the formation of microbubbles in continuous blood flow. View Full-Text
Keywords: low cost biochips; nonlithographic technique; xurography; blood flow; bifurcations; microbubbles; biomicrofluidics low cost biochips; nonlithographic technique; xurography; blood flow; bifurcations; microbubbles; biomicrofluidics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pinto, E.; Faustino, V.; Rodrigues, R.O.; Pinho, D.; Garcia, V.; Miranda, J.M.; Lima, R. A Rapid and Low-Cost Nonlithographic Method to Fabricate Biomedical Microdevices for Blood Flow Analysis. Micromachines 2015, 6, 121-135.

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