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A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array
Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong, China
* Authors to whom correspondence should be addressed.
Received: 11 February 2012; in revised form: 15 March 2012 / Accepted: 27 March 2012 / Published: 29 March 2012
Abstract: This paper presents an integrated digitally controllable microfluidic system for continuous solution supply with a real-time concentration control. This system contains multiple independently operating mixing modules, each integrated with two vortex micropumps, two Tesla valves and a micromixer. The interior surface of the system is made of biocompatible materials using a polymer micro-fabrication process and thus its operation can be applied to chemicals and bio-reagents. In each module, pumping of fluid is achieved by the vortex micropump working with the rotation of a micro-impeller. The downstream fluid mixing is based on mechanical vibrations driven by a lead zirconate titanate ceramic diaphragm actuator located below the mixing chamber. We have conducted experiments to prove that the addition of the micro-pillar structures to the mixing chamber further improves the mixing performance. We also developed a computer-controlled automated driver system to control the real-time fluid mixing and concentration regulation with the mixing module array. This research demonstrates the integration of digitally controllable polymer-based microfluidic modules as a fully functional system, which has great potential in the automation of many bio-fluid handling processes in bio-related applications.
Keywords: microfluidic; pump; mix; tesla; valve; integration
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MDPI and ACS Style
Lam, R.H.W.; Li, W.J. A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array. Micromachines 2012, 3, 279-294.
Lam RHW, Li WJ. A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array. Micromachines. 2012; 3(2):279-294.
Lam, Raymond H. W.; Li, Wen J. 2012. "A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array." Micromachines 3, no. 2: 279-294.