Micromachines 2012, 3(2), 279-294; doi:10.3390/mi3020279

A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array

* email and * email
Received: 11 February 2012; in revised form: 15 March 2012 / Accepted: 27 March 2012 / Published: 29 March 2012
(This article belongs to the Special Issue Micro Flow Controllers)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This paper presents an integrated digitally controllable microfluidic system for continuous solution supply with a real-time concentration control. This system contains multiple independently operating mixing modules, each integrated with two vortex micropumps, two Tesla valves and a micromixer. The interior surface of the system is made of biocompatible materials using a polymer micro-fabrication process and thus its operation can be applied to chemicals and bio-reagents. In each module, pumping of fluid is achieved by the vortex micropump working with the rotation of a micro-impeller. The downstream fluid mixing is based on mechanical vibrations driven by a lead zirconate titanate ceramic diaphragm actuator located below the mixing chamber. We have conducted experiments to prove that the addition of the micro-pillar structures to the mixing chamber further improves the mixing performance. We also developed a computer-controlled automated driver system to control the real-time fluid mixing and concentration regulation with the mixing module array. This research demonstrates the integration of digitally controllable polymer-based microfluidic modules as a fully functional system, which has great potential in the automation of many bio-fluid handling processes in bio-related applications.
Keywords: microfluidic; pump; mix; tesla; valve; integration
PDF Full-text Download PDF Full-Text [2069 KB, uploaded 29 March 2012 09:43 CEST]

Export to BibTeX |

MDPI and ACS Style

Lam, R.H.W.; Li, W.J. A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array. Micromachines 2012, 3, 279-294.

AMA Style

Lam RHW, Li WJ. A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array. Micromachines. 2012; 3(2):279-294.

Chicago/Turabian Style

Lam, Raymond H. W.; Li, Wen J. 2012. "A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array." Micromachines 3, no. 2: 279-294.

Micromachines EISSN 2072-666X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert