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• van Lintel, H
• Mernier, G
• Renaud, P
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• Mernier, G
• Renaud, P
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• van Lintel, H
• Mernier, G
• Renaud, P

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Micromachines 2012, 3(2), 218-224; doi:10.3390/mi3020218

Communication

High-Throughput Micro-Debubblers for Bubble Removal with Sub-Microliter Dead Volume

Harald van Lintel* , Guillaume Mernier and Philippe Renaud

Microsystems Laboratory LMIS4, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 17, CH-1015 Lausanne, Switzerland

* Author to whom correspondence should be addressed.

Received: 13 February 2012; in revised form: 12 March 2012 / Accepted: 22 March 2012 / Published: 23 March 2012

Download PDF Full-Text [610 KB, uploaded 23 March 2012 15:34 CET]

Abstract: We present the fabrication and evaluation of microdebubblers that are able to remove large bubbles while keeping a very low dead volume. The devices use a polytetrafluoroethylene membrane that is permeable to air in order to filter air bubbles out of an aqueous sample. The dead volume of the devices is less than one microliter, but bubbles as large as 60 microliters can be removed. This simple solution can be very useful for microfluidic devices for chemical or biological analysis that suffer from channel clogging due to the presence of bubbles in their sample. One embodiment is particularly suited for buffer solutions with living cells.

Keywords: microfluidics; debubbler; air bubbles; yeast cells

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