Next Article in Journal
Influence of Cooking (Microwaving and Broiling) on Cylindrospermopsin Concentration in Muscle of Nile Tilapia (Oreochromis niloticus) and Characterization of Decomposition Products
Next Article in Special Issue
Aflatoxin B1 Tolerance and Accumulation in Black Soldier Fly Larvae (Hermetia illucens) and Yellow Mealworms (Tenebrio molitor)
Previous Article in Journal
Potential Use of Chemoprotectants against the Toxic Effects of Cyanotoxins: A Review
Previous Article in Special Issue
Doses of Immunogen Contribute to Specificity Spectrums of Antibodies against Aflatoxin
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle
Toxins 2017, 9(6), 176; doi:10.3390/toxins9060176

Inhibitory Activities of Blasticidin S Derivatives on Aflatoxin Production by Aspergillus Flavus

1
Division of Microbiology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
2
Department of Food and Life Sciences, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Tokyo 252-5201, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Shohei Sakuda
Received: 11 April 2017 / Revised: 22 May 2017 / Accepted: 22 May 2017 / Published: 26 May 2017
(This article belongs to the Collection Aflatoxins)
View Full-Text   |   Download PDF [976 KB, uploaded 26 May 2017]   |  

Abstract

Blasticidin S (BcS) is a protein synthesis inhibitor which shows strong growth inhibitory activity against a number of microorganisms. However, BcS inhibited aflatoxin production by Aspergillus flavus without affecting its growth. In order to obtain information about the structure–activity relationship of BcS as an aflatoxin production inhibitor, BcS derivatives were prepared and their aflatoxin production inhibitory activities were evaluated. Among five derivatives, blasticidin S carboxymethyl ester, deaminohydroxyblasticidin S, and pyrimidinoblasticidin S showed inhibitory activity, while the others did not. The IC50 value for aflatoxin production of the carboxymethyl ester derivative was one-fifth of that of BcS although their antimicrobial activities were almost the same. These results indicate that the inhibitory activity of BcS against aflatoxin production was enhanced by esterification of its carboxyl group and that the carboxymethyl ester derivative might be more suitable for practical use than BcS because of the specificity of the carboxymethyl ester derivative, which inhibited aflatoxin production more than BcS. View Full-Text
Keywords: aflatoxin; blasticidin S; structure–activity relationship aflatoxin; blasticidin S; structure–activity relationship
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yoshinari, T.; Sugita-Konishi, Y.; Ohnishi, T.; Terajima, J. Inhibitory Activities of Blasticidin S Derivatives on Aflatoxin Production by Aspergillus Flavus. Toxins 2017, 9, 176.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top