Next Article in Journal
Use of Cold Atmospheric Plasma to Detoxify Hazelnuts from Aflatoxins
Next Article in Special Issue
Impact of CDT Toxin on Human Diseases
Previous Article in Journal
A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Toxins 2016, 8(5), 121; doi:10.3390/toxins8050121

Dynamic Duo—The Salmonella Cytolethal Distending Toxin Combines ADP-Ribosyltransferase and Nuclease Activities in a Novel Form of the Cytolethal Distending Toxin

Department of Food Science, Cornell University, Ithaca, NY 14850 USA
*
Author to whom correspondence should be addressed.
Academic Editor: Joseph M. DiRienzo
Received: 3 March 2016 / Revised: 30 March 2016 / Accepted: 15 April 2016 / Published: 25 April 2016
View Full-Text   |   Download PDF [844 KB, uploaded 25 April 2016]   |  

Abstract

The cytolethal distending toxin (CDT) is a well characterized bacterial genotoxin encoded by several Gram-negative bacteria, including Salmonella enterica (S. enterica). The CDT produced by Salmonella (S-CDT) differs from the CDT produced by other bacteria, as it utilizes subunits with homology to the pertussis and subtilase toxins, in place of the traditional CdtA and CdtC subunits. Previously, S-CDT was thought to be a unique virulence factor of S. enterica subspecies enterica serotype Typhi, lending to its classification as the “typhoid toxin.” Recently, this important virulence factor has been identified and characterized in multiple nontyphoidal Salmonella (NTS) serotypes as well. The significance of S-CDT in salmonellosis with regards to the: (i) distribution of S-CDT encoding genes among NTS serotypes, (ii) contributions to pathogenicity, (iii) regulation of S-CDT expression, and (iv) the public health implication of S-CDT as it relates to disease severity, are reviewed here. View Full-Text
Keywords: cytolethal distending toxin; Salmonella; nontyphoidal; typhoid toxin; DNA damage; virulence factor cytolethal distending toxin; Salmonella; nontyphoidal; typhoid toxin; DNA damage; virulence factor
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Miller, R.; Wiedmann, M. Dynamic Duo—The Salmonella Cytolethal Distending Toxin Combines ADP-Ribosyltransferase and Nuclease Activities in a Novel Form of the Cytolethal Distending Toxin. Toxins 2016, 8, 121.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top