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Toxins 2016, 8(4), 122; doi:10.3390/toxins8040122

A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions

Department of Dermatology and Venerology, University of Cologne, Cologne 50937, Germany
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Author to whom correspondence should be addressed.
Academic Editors: Jay Fox and José María Gutiérrez
Received: 14 March 2016 / Revised: 11 April 2016 / Accepted: 19 April 2016 / Published: 23 April 2016
(This article belongs to the Special Issue Snake Venom Metalloproteinases)
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Abstract

Since the discovery of the first disintegrin protein from snake venom and the following identification of a mammalian membrane-anchored metalloprotease-disintegrin implicated in fertilization, almost three decades of studies have identified additional members of these families and several biochemical mechanisms regulating their expression and activity in the cell. Most importantly, new in vivo functions have been recognized for these proteins including cell partitioning during development, modulation of inflammatory reactions, and development of cancers. In this review, we will overview the a disintegrin and metalloprotease (ADAM) family of proteases highlighting some of the major research achievements in the analysis of ADAMs’ function that have underscored the importance of these proteins in physiological and pathological processes over the years. View Full-Text
Keywords: ADAM; disintegrin; SVMP ADAM; disintegrin; SVMP
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Giebeler, N.; Zigrino, P. A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions. Toxins 2016, 8, 122.

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