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Toxins 2016, 8(7), 220; doi:10.3390/toxins8070220

Impact of CDT Toxin on Human Diseases

1
Microbes, Inflammation, Intestin et Susceptibilité de l’Hôte (M2iSH), Clermont Université, Université d’Auvergne; INSERM U1071; INRA USC2018, Clermont-Ferrand 63000, France
2
Laboratoire de Bactériologie, Centre Hospitalier Universitaire, Clermont-Ferrand 63000, France
3
Institut Universitaire de Technologie, Université d’Auvergne, Aubière 63170, France
*
Authors to whom correspondence should be addressed.
Academic Editors: Joseph M. DiRienzo and Gerald E. Duhamel
Received: 10 February 2016 / Revised: 1 July 2016 / Accepted: 6 July 2016 / Published: 15 July 2016
View Full-Text   |   Download PDF [1467 KB, uploaded 15 July 2016]   |  

Abstract

Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulation, tissue damage). Some works even suggest a potential involvement of CDT in cancers. In this review, we will discuss these different aspects. View Full-Text
Keywords: CDT toxin; CDT-producing bacteria; DNA damage CDT toxin; CDT-producing bacteria; DNA damage
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Faïs, T.; Delmas, J.; Serres, A.; Bonnet, R.; Dalmasso, G. Impact of CDT Toxin on Human Diseases. Toxins 2016, 8, 220.

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