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Toxins 2016, 8(12), 374; doi:10.3390/toxins8120374

Abobotulinum Toxin A in the Treatment of Chronic Low Back Pain

Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
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Author to whom correspondence should be addressed.
Academic Editor: Cesare Montecucco
Received: 13 October 2016 / Revised: 8 December 2016 / Accepted: 9 December 2016 / Published: 15 December 2016
(This article belongs to the Collection Botulinum Toxins on Human Pain)
View Full-Text   |   Download PDF [232 KB, uploaded 15 December 2016]

Abstract

Chronic low back pain is a debilitating condition with a complex and multifactorial pathophysiology. Botulinum neurotoxins (BoNTs) have strong analgesic effects, as shown in both animal models of pain and in human beings. A randomized, double-blind, placebo-controlled, parallel format study to investigate the efficacy of abobotulinum toxin A (aboA) in chronic low back pain was conducted. The study cohort consisted of 18 patients who received 100 units of aboA into each of the five lumbar extensor spinae muscles unilaterally or bilaterally (total dose 500 to 1000 units), and 19 who received normal saline of the same volume. The level of pain and quality of life were assessed using the visual analogue scale (VAS) and three questionnaires including the Oswestry Low Back Pain Disability Questionnaire (OLBPDQ). Patients’ perception of improvement was recorded via patient global impression of change (PGIC). The primary outcome measure, the proportion of responders with VAS of <4 at 6 weeks, was not met, but the data was significantly in favor of aboA at 4 weeks (p = 0.008). The total Oswestry score representing quality of life improved in the aboA group compared to the placebo group (p = 0.0448). Moreover, significantly more patients reported their low back pain as “much improved” in the abobotulinum toxin A group (0.0293). View Full-Text
Keywords: low back pain; abobotulinum toxin A; botulinum neurotoxin; randomized controlled trial low back pain; abobotulinum toxin A; botulinum neurotoxin; randomized controlled trial
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Machado, D.; Kumar, A.; Jabbari, B. Abobotulinum Toxin A in the Treatment of Chronic Low Back Pain. Toxins 2016, 8, 374.

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