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Toxins 2016, 8(12), 373; doi:10.3390/toxins8120373

Limited Link between Oxidative Stress and Ochratoxin A—Induced Renal Injury in an Acute Toxicity Rat Model

1,3
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1
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1
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1
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1,3,4
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1,3,4
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2,* and 1,3,4,*
1
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, No. 17 Tsinghua Donglu, Beijing 100083, China
2
State key Laboratory of Agrobiotechnology, Department of Animal Physiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China
3
The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing 100083, China
4
Beijing Laboratory of Food Quality and Safety, Beijing 100083, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Richard A. Manderville and Annie Pfohl-Leszkowicz
Received: 20 October 2016 / Revised: 7 December 2016 / Accepted: 8 December 2016 / Published: 14 December 2016
(This article belongs to the Collection Ochratoxins-Collection)
View Full-Text   |   Download PDF [2250 KB, uploaded 14 December 2016]   |  

Abstract

Ochratoxin A (OTA) displays nephrotoxicity and hepatotoxicity. However, in the acute toxicity rat model, there is no evidence on the relationship between OTA and nephrotoxicity and hepatotoxicity. Based on this, the integrated analysis of physiological status, damage biomarkers, oxidative stress, and DNA damage were performed. After OTA treatment, the body weight decreased and AST, ALP, TP, and BUN levels in serum increased. Hydropic degeneration, swelling, vacuolization, and partial drop occurred in proximal tubule epithelial cells. PCNA and Kim-1 were dose-dependently increased in the kidney, but Cox-2 expression and proliferation were not found in the liver. In OTA-treated kidneys, the mRNA expressions of Kim-1, Cox-2, Lcn2, and Clu were dose-dependently increased. The mRNA expressions of Vim and Cox-2 were decreased in OTA-treated livers. Some oxidative stress indicators were altered in the kidneys (ROS and SOD) and livers (SOD and GSH). DNA damage and oxidative DNA damage were not found. In conclusion, there is a limited link between oxidative stress and OTA-induced renal injury in an acute toxicity rat model. View Full-Text
Keywords: Ochratoxin A; acute toxicity; nephrotoxicity; oxidative stress; DNA damage Ochratoxin A; acute toxicity; nephrotoxicity; oxidative stress; DNA damage
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Zhu, L.; Yu, T.; Qi, X.; Gao, J.; Huang, K.; He, X.; Luo, H.; Xu, W. Limited Link between Oxidative Stress and Ochratoxin A—Induced Renal Injury in an Acute Toxicity Rat Model. Toxins 2016, 8, 373.

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