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Toxins 2015, 7(4), 1174-1191; doi:10.3390/toxins7041174

Comparative Investigation of the Efficacy of Three Different Adsorbents against OTA-Induced Toxicity in Broiler Chickens

1
Faculty of Veterinary Medicine, University of Belgrade, Bulevar oslobodjenja 18, 11000 Belgrade, Serbia
2
Institute of Meat Hygiene and Technology, Kacanskog 13, 11040 Belgrade, Serbia
3
Patent Co. d.o.o, 24211 Mišićevo, Serbia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Annie Pfohl-Leszkowicz
Received: 1 December 2014 / Revised: 5 March 2015 / Accepted: 9 March 2015 / Published: 3 April 2015
(This article belongs to the Special Issue Detoxification of Mycotoxins)
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Abstract

The aim of our study was to determine the efficacy of three different adsorbents, inorganic (modified zeolite), organic (esterified glucomannans) and mixed (inorganic and organic components, with the addition of enzymes), in protecting broilers from the toxic effects of ochratoxin A in feed. Broilers were fed diets containing 2 mg/kg of ochratoxin A (OTA) and supplemented with adsorbents at the recommended concentration of 2 g/kg for 21 days. The presence of OTA led to a notable reduction in body weight, lower weight gain, increased feed conversion and induced histopathological changes in the liver and kidneys. The presence of inorganic, organic and mixed adsorbents in contaminated feed only partially reduced the negative effects of OTA on the broiler performances. Broilers that were fed with adsorbent-supplemented feed reached higher body weight (17.96%, 19.09% and 13.59%), compared to the group that received only OTA. The presence of adsorbents partially alleviated the reduction in feed consumption (22.68%, 12.91% and 10.59%), and a similar effect was observed with feed conversion. The applied adsorbents have also reduced the intensity of histopathological changes caused by OTA; however, they were not able to prevent their onset. After the withdrawal of the toxin and adsorbents from the feed (21–42 days), all previously observed disturbances in broilers were reduced, but more remarkably in broilers fed with adsorbents. View Full-Text
Keywords: ochratoxin A; adsorbents; performance; pathohistological examination ochratoxin A; adsorbents; performance; pathohistological examination
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nedeljković-Trailović, J.; Trailović, S.; Resanović, R.; Milićević, D.; Jovanovic, M.; Vasiljevic, M. Comparative Investigation of the Efficacy of Three Different Adsorbents against OTA-Induced Toxicity in Broiler Chickens. Toxins 2015, 7, 1174-1191.

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