Next Article in Journal
Ophiobolin A from Bipolaris oryzae Perturbs Motility and Membrane Integrities of Porcine Sperm and Induces Cell Death on Mammalian Somatic Cell Lines
Next Article in Special Issue
Increased Circulating Levels of Vitamin D Binding Protein in MS Patients
Previous Article in Journal
The Adsorption of Ochratoxin A by Lactobacillus Species
Previous Article in Special Issue
Type I Interferons as Regulators of Human Antigen Presenting Cell Functions
Article Menu

Export Article

Open AccessArticle
Toxins 2014, 6(9), 2840-2856; doi:10.3390/toxins6092840

Oxidized Lipids and Lysophosphatidylcholine Induce the Chemotaxis, Up-Regulate the Expression of CCR9 and CXCR4 and Abrogate the Release of IL-6 in Human Monocytes

Department of Physiology, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo 0317, Norway
*
Authors to whom correspondence should be addressed.
Received: 24 July 2014 / Revised: 8 September 2014 / Accepted: 15 September 2014 / Published: 23 September 2014
(This article belongs to the Collection Toxicity and Therapeutic Interventions in the Immune System)
View Full-Text   |   Download PDF [1088 KB, uploaded 23 September 2014]   |  

Abstract

Lipids through regulation of chronic inflammation play key roles in the development of various diseases. Here, we report that a mixed population of human primary monocytes migrated towards LPC, as well as oxidized linoleic acid isoforms 9-S-HODE, 9-R-HODE and 13-R-HODE. Incubation with 9-R-HODE, 13-R-HODE and LPC resulted in increased expression of CXCR4, the receptor for SDF-1α/CXCL12, correlated with increased monocyte migration towards SDF-1α/CXCL12. Further, we report increased expression of CCR9, the receptor for TECK/CCL25, after stimulation with these lipids. Upon examining the migratory response towards TECK/CCL25, it was observed that an increase in CCR9 expression upon pre-treatment with 9-S-HODE, 9-R-HODE, 13-R-HODE and LPC resulted in increased migration of monocytes expressing CCR9. Only LPC but not any other lipid examined increased the influx of intracellular Ca2+ in monocytes. Finally, 9-S-HODE, 9-R-HODE, 13-R-HODE, or LPC inhibited the release of IL-6 from monocytes suggesting that these lipids may play important role in controlling inflammatory responses. View Full-Text
Keywords: CCR9; CXCR4; HODE; LPC; monocytes; SDF-1α; TECK CCR9; CXCR4; HODE; LPC; monocytes; SDF-1α; TECK
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Rolin, J.; Vego, H.; Maghazachi, A.A. Oxidized Lipids and Lysophosphatidylcholine Induce the Chemotaxis, Up-Regulate the Expression of CCR9 and CXCR4 and Abrogate the Release of IL-6 in Human Monocytes. Toxins 2014, 6, 2840-2856.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top