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Toxins 2013, 5(6), 1180-1201; doi:10.3390/toxins5061180
Review

Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis

*  and
Received: 9 May 2013; in revised form: 5 June 2013 / Accepted: 13 June 2013 / Published: 18 June 2013
(This article belongs to the Special Issue Diphtheria Toxin)
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Abstract: Heparin-binding EGF-like growth factor (HB-EGF) belongs to the EGF family of growth factors. It is biologically active either as a molecule anchored to the membrane or as a soluble form released by proteolytic cleavage of the extracellular domain. HB-EGF is involved in relevant physiological and pathological processes spanning from proliferation and apoptosis to morphogenesis. We outline here the main activities of HB-EGF in connection with normal or neoplastic differentiative or proliferative events taking place primitively in the hematopoietic microenvironment.
Keywords: HB-EGF; GPCR; EGFR/ErbB/HER; Hematopoiesis; Leukemia; Myeloma HB-EGF; GPCR; EGFR/ErbB/HER; Hematopoiesis; Leukemia; Myeloma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Vinante, F.; Rigo, A. Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis. Toxins 2013, 5, 1180-1201.

AMA Style

Vinante F, Rigo A. Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis. Toxins. 2013; 5(6):1180-1201.

Chicago/Turabian Style

Vinante, Fabrizio; Rigo, Antonella. 2013. "Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis." Toxins 5, no. 6: 1180-1201.



Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert