Next Article in Journal
Computational Design of Peptide Ligands for Ochratoxin A
Next Article in Special Issue
pH-Triggered Conformational Switching along the Membrane Insertion Pathway of the Diphtheria Toxin T-Domain
Previous Article in Journal
Determinants of pH-Dependent Modulation of Translocation in Dermonecrotic G-Protein-Deamidating Toxins
Previous Article in Special Issue
Insights into Diphthamide, Key Diphtheria Toxin Effector
Article Menu

Export Article

Open AccessReview
Toxins 2013, 5(6), 1180-1201; doi:10.3390/toxins5061180

Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis

Department of Medicine, Section of Hematology, Cancer Research & Cell Biology Laboratory, University of Verona, Verona, Italy
*
Author to whom correspondence should be addressed.
Received: 9 May 2013 / Revised: 5 June 2013 / Accepted: 13 June 2013 / Published: 18 June 2013
(This article belongs to the Special Issue Diphtheria Toxin)
View Full-Text   |   Download PDF [927 KB, uploaded 18 June 2013]   |  

Abstract

Heparin-binding EGF-like growth factor (HB-EGF) belongs to the EGF family of growth factors. It is biologically active either as a molecule anchored to the membrane or as a soluble form released by proteolytic cleavage of the extracellular domain. HB-EGF is involved in relevant physiological and pathological processes spanning from proliferation and apoptosis to morphogenesis. We outline here the main activities of HB-EGF in connection with normal or neoplastic differentiative or proliferative events taking place primitively in the hematopoietic microenvironment. View Full-Text
Keywords: HB-EGF; GPCR; EGFR/ErbB/HER; Hematopoiesis; Leukemia; Myeloma HB-EGF; GPCR; EGFR/ErbB/HER; Hematopoiesis; Leukemia; Myeloma
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Vinante, F.; Rigo, A. Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis. Toxins 2013, 5, 1180-1201.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top