Special Issue "Diphtheria Toxin"
Deadline for manuscript submissions: closed (20 September 2014)
Prof. Dr. Daniel Gillet (Website)
Service d’Ingénierie Moléculaire des Protéines (SIMOPRO), IBITECS, CEA, LabEx LERMIT, Université Paris-Saclay, F-91191 Gif Sur Yvette, France
Interests: toxins, bacterial toxins, diphtheria toxin, ricin toxin, Shiga toxins, botulinum toxins, CBRN, Biodefense
Diphtheria toxin was the first bacterial toxin to be discovered. It is among the best-known bacterial toxins acting inside cells. This exquisitely sophisticated piece of molecular machinery regroups three main distinct activities, each relying on very different biological properties: the recognition of a ubiquitous cell-surface protein in order to get internalized by cells, the capacity to cross the membrane barrier of intracellular trafficking compartments and a highly specific catalytic activity capable of neutralizing protein synthesis. Anti-diphtheria toxin vaccination with toxoid started almost a century ago and still has a tremendous impact on public health, preventing each year the deaths of tens of thousands of children. More recently, sophisticated protein engineering of diphtheria toxin led to many biotechnological applications for research, and to the first approved anti-tumor targeted toxin for the treatment of lymphomas. However, there is still a lot to discover about the molecular details of the various steps of the mechanism of action of the toxin, as modern biology enables to understand molecular events at atomic resolution and in living cells. There is little doubt that in the future, several new biological drugs will be based on modified fragments of this fascinating protein.
Dr. Daniel Gillet
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on theInstructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.
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- diphtheria toxin
- targeted toxin
- membrane translocation