Special Issue "Diphtheria Toxin"


A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: closed (20 September 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Daniel Gillet

Laboratory of Molecular Toxinology and Biotechnology (LTMB), Molecular engineering of proteins (SIMOPRO), Life Sciences Division (DSV), Institute of Biology and Technology Saclay (iBiTec-S), French Alternative Energies and Atomic Energy Commission (CEA), F-91191 Gif sur Yvette, France
Website: http://ibitecs.cea.fr/dsv/ibitecs/english/Pages/units/simopro/ltmb/toxin-membrane-interactions.aspx
Fax: +33 6 88 21 08 73
Interests: toxins, bacterial toxins, diphtheria toxin, ricin toxin, Shiga toxins, botulinum toxins, CBRN, Biodefense

Special Issue Information

Dear Colleagues,

Diphtheria toxin was the first bacterial toxin to be discovered. It is among the best-known bacterial toxins acting inside cells. This exquisitely sophisticated piece of molecular machinery regroups three main distinct activities, each relying on very different biological properties: the recognition of a ubiquitous cell-surface protein in order to get internalized by cells, the capacity to cross the membrane barrier of intracellular trafficking compartments and a highly specific catalytic activity capable of neutralizing protein synthesis. Anti-diphtheria toxin vaccination with toxoid started almost a century ago and still has a tremendous impact on public health, preventing each year the deaths of tens of thousands of children. More recently, sophisticated protein engineering of diphtheria toxin led to many biotechnological applications for research, and to the first approved anti-tumor targeted toxin for the treatment of lymphomas. However, there is still a lot to discover about the molecular details of the various steps of the mechanism of action of the toxin, as modern biology enables to understand molecular events at atomic resolution and in living cells. There is little doubt that in the future, several new biological drugs will be based on modified fragments of this fascinating protein.

Dr. Daniel Gillet
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on theInstructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 800 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • diphtheria toxin
  • toxoid
  • targeted toxin
  • membrane translocation
  • HB-EGF
  • ADP-ribosylation

Published Papers (3 papers)

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Displaying article 1-3
p. 1362-1380
Toxins 2013, 5(8), 1362-1380; doi:10.3390/toxins5081362
Received: 8 July 2013 / Revised: 26 July 2013 / Accepted: 26 July 2013 / Published: 6 August 2013
Show/Hide Abstract | Cited by 11 | PDF Full-text (2208 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Diphtheria Toxin)
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p. 1180-1201
by  and
Toxins 2013, 5(6), 1180-1201; doi:10.3390/toxins5061180
Received: 9 May 2013 / Revised: 5 June 2013 / Accepted: 13 June 2013 / Published: 18 June 2013
Show/Hide Abstract | Cited by 4 | PDF Full-text (927 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Diphtheria Toxin)
p. 958-968
by , , ,  and
Toxins 2013, 5(5), 958-968; doi:10.3390/toxins5050958
Received: 14 March 2013 / Revised: 17 April 2013 / Accepted: 26 April 2013 / Published: 3 May 2013
Show/Hide Abstract | Cited by 7 | PDF Full-text (1001 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Diphtheria Toxin)
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Last update: 5 November 2014

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