Next Article in Journal
ESI-MS/MS Identification of a Bradykinin-Potentiating Peptide from Amazon Bothrops atrox Snake Venom Using a Hybrid Qq-oaTOF Mass Spectrometer
Previous Article in Journal
Venom Peptides as a Rich Source of Cav2.2 Channel Blockers
Previous Article in Special Issue
Bacillus anthracis Protective Antigen Kinetics in Inhalation Spore-Challenged Untreated or Levofloxacin/ Raxibacumab-Treated New Zealand White Rabbits
Toxins 2013, 5(2), 315-326; doi:10.3390/toxins5020315
Review

Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis

1,†
, 1,2,†
 and 1,3,4,*
Received: 4 January 2013; Accepted: 31 January 2013 / Published: 6 February 2013
(This article belongs to the Special Issue Anthrax Toxin)
Download PDF [484 KB, uploaded 6 February 2013]
Abstract: The genes encoding Anthrax Toxin Receptors (ANTXRs) were originally identified based on expression in endothelial cells suggesting a role in angiogenesis. The focus of this review is to discuss what has been learned about the physiological roles of these receptors through evaluation of the Antxr knockout mouse phenotypes. Mice mutant in Antxr genes have defects in extracellular matrix homeostasis. We discuss how knowledge of physiological ANTXR function relates to what is already known about anthrax intoxication.
Keywords: anthrax toxin receptors; MT1-MMP; extracellular matrix homeostasis; anthrax intoxication anthrax toxin receptors; MT1-MMP; extracellular matrix homeostasis; anthrax intoxication
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Reeves, C.; Charles-Horvath, P.; Kitajewski, J. Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis. Toxins 2013, 5, 315-326.

AMA Style

Reeves C, Charles-Horvath P, Kitajewski J. Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis. Toxins. 2013; 5(2):315-326.

Chicago/Turabian Style

Reeves, Claire; Charles-Horvath, Pelisa; Kitajewski, Jan. 2013. "Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis." Toxins 5, no. 2: 315-326.


Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert