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The Use of Convection-Enhanced Delivery with Liposomal Toxins in Neurooncology
Molecular Therapeutics Laboratory, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, Mission Center Building, Rm. 226, San Francisco, CA 94103, USA
* Author to whom correspondence should be addressed.
Received: 28 February 2011; in revised form: 25 March 2011 / Accepted: 25 March 2011 / Published: 31 March 2011
Abstract: Liposomes have long been effective delivery vehicles for transport of toxins to peripheral cancers. The combination of convection-enhanced delivery (CED) with liposomal toxins was originally proposed to circumvent the limited delivery of intravascular liposomes to the central nervous system (CNS) due to the blood-brain-barrier (BBB). CED offers markedly improved distribution of infused therapeutics within the CNS compared to direct injection or via drug eluting polymers, both of which depend on diffusion for parenchymal distribution. This review examines the basis for improved delivery of liposomal toxins via CED within the CNS, and discusses preclinical and clinical experience with these therapeutic techniques. How CED and liposomal technologies may influence future neurooncologic treatments are also considered.
Keywords: blood-brain-barrier; convection-enhanced delivery; diffusion; glioma; liposome; neurooncology
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Fiandaca, M.S.; Berger, M.S.; Bankiewicz, K.S. The Use of Convection-Enhanced Delivery with Liposomal Toxins in Neurooncology. Toxins 2011, 3, 369-397.
Fiandaca MS, Berger MS, Bankiewicz KS. The Use of Convection-Enhanced Delivery with Liposomal Toxins in Neurooncology. Toxins. 2011; 3(4):369-397.
Fiandaca, Massimo S.; Berger, Mitchel S.; Bankiewicz, Krystof S. 2011. "The Use of Convection-Enhanced Delivery with Liposomal Toxins in Neurooncology." Toxins 3, no. 4: 369-397.