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Toxins 2011, 3(4), 369-397; doi:10.3390/toxins3040369

The Use of Convection-Enhanced Delivery with Liposomal Toxins in Neurooncology

Molecular Therapeutics Laboratory, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, Mission Center Building, Rm. 226, San Francisco, CA 94103, USA
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Received: 28 February 2011 / Revised: 25 March 2011 / Accepted: 25 March 2011 / Published: 31 March 2011
(This article belongs to the Special Issue Immunotoxins)
View Full-Text   |   Download PDF [663 KB, 1 April 2011; original version 31 March 2011]   |  

Abstract

Liposomes have long been effective delivery vehicles for transport of toxins to peripheral cancers. The combination of convection-enhanced delivery (CED) with liposomal toxins was originally proposed to circumvent the limited delivery of intravascular liposomes to the central nervous system (CNS) due to the blood-brain-barrier (BBB). CED offers markedly improved distribution of infused therapeutics within the CNS compared to direct injection or via drug eluting polymers, both of which depend on diffusion for parenchymal distribution. This review examines the basis for improved delivery of liposomal toxins via CED within the CNS, and discusses preclinical and clinical experience with these therapeutic techniques. How CED and liposomal technologies may influence future neurooncologic treatments are also considered. View Full-Text
Keywords: blood-brain-barrier; convection-enhanced delivery; diffusion; glioma; liposome; neurooncology blood-brain-barrier; convection-enhanced delivery; diffusion; glioma; liposome; neurooncology
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Fiandaca, M.S.; Berger, M.S.; Bankiewicz, K.S. The Use of Convection-Enhanced Delivery with Liposomal Toxins in Neurooncology. Toxins 2011, 3, 369-397.

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