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Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells
INRA, USC Molecular and Cellular Pathogenesis of Escherichia coli Infections, Toulouse, F-31300, France
Inserm, U1043, Toulouse, F-31300, France
University of Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, F-31300, France
CNRS, U5282, Toulouse, F-31300, France
CHU Toulouse, Hôpital Purpan, Service de Bactériologie-Hygiène, Toulouse, F-31300, France
* Author to whom correspondence should be addressed.
Received: 18 February 2011; in revised form: 16 March 2011 / Accepted: 16 March 2011 / Published: 29 March 2011
Abstract: Cycle inhibiting factors (Cifs) are type III secreted effectors produced by diverse pathogenic bacteria. Cifs are “cyclomodulins” that inhibit the eukaryotic host cell cycle and also hijack other key cellular processes such as those controlling the actin network and apoptosis. This review summarizes current knowledge on Cif since its first characterization in enteropathogenic Escherichia coli, the identification of several xenologues in distant pathogenic bacteria, to its structure elucidation and the recent deciphering of its mode of action. Cif impairs the host ubiquitin proteasome system through deamidation of ubiquitin or the ubiquitin-like protein NEDD8 that regulates Cullin-Ring-ubiquitin Ligase (CRL) complexes. The hijacking of the ubiquitin-dependent degradation pathway of host cells results in the modulation of various cellular functions such as epithelium renewal, apoptosis and immune response. Cif is therefore a powerful weapon in the continuous arm race that characterizes host-bacteria interactions.
Keywords: bacterial toxin; type III secretion system; eukaryotic cell cycle; NEDD8; ubiquitin; cullin-RING E3 ubiquitin ligase
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MDPI and ACS Style
Taieb, F.; Nougayrède, J.-P.; Oswald, E. Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells. Toxins 2011, 3, 356-368.
Taieb F, Nougayrède J-P, Oswald E. Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells. Toxins. 2011; 3(4):356-368.
Taieb, Frédéric; Nougayrède, Jean-Philippe; Oswald, Eric. 2011. "Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells." Toxins 3, no. 4: 356-368.