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Monitoring Radiographic Brain Tumor Progression
Division of Neurosurgery, Duke University Medical Center, Box 3807, Durham, NC 27710, USA
* Author to whom correspondence should be addressed.
Received: 31 January 2011; in revised form: 3 February 2011 / Accepted: 11 March 2011 / Published: 15 March 2011
Abstract: Determining radiographic progression in primary malignant brain tumors has posed a significant challenge to the neuroncology community. Glioblastoma multiforme (GBM, WHO Grade IV) through its inherent heterogeneous enhancement, growth patterns, and irregular nature has been difficult to assess for progression. Our ability to detect tumor progression radiographically remains inadequate. Despite the advanced imaging techniques, detecting tumor progression continues to be a clinical challenge. Here we review the different criteria used to detect tumor progression, and highlight the inherent challenges with detection of progression.
Keywords: glioblastoma; radiographic progression; tumor progression; MRI
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Mehta, A.I.; Kanaly, C.W.; Friedman, A.H.; Bigner, D.D.; Sampson, J.H. Monitoring Radiographic Brain Tumor Progression. Toxins 2011, 3, 191-200.
Mehta AI, Kanaly CW, Friedman AH, Bigner DD, Sampson JH. Monitoring Radiographic Brain Tumor Progression. Toxins. 2011; 3(3):191-200.
Mehta, Ankit I.; Kanaly, Charles W.; Friedman, Allan H.; Bigner, Darell D.; Sampson, John H. 2011. "Monitoring Radiographic Brain Tumor Progression." Toxins 3, no. 3: 191-200.