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Toxins 2011, 3(1), 17-42; doi:10.3390/toxins3010017

Peptide Neurotoxins That Affect Voltage-Gated Calcium Channels: A Close-Up on ω-Agatoxins

IBMM, UMR 5247, CNRS, Max Mousseron Institut of Biomolecules, Montpellier 1 & 2, Place E. Bataillon, Montpellier, France
* Author to whom correspondence should be addressed.
Received: 14 October 2010 / Revised: 23 December 2010 / Accepted: 30 December 2010 / Published: 4 January 2011
(This article belongs to the Special Issue Neurotoxins of Biological Origin)
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Peptide neurotoxins found in animal venoms have gained great interest in the field of neurotransmission. As they are high affinity ligands for calcium, potassium and sodium channels, they have become useful tools for studying channel structure and activity. Peptide neurotoxins represent the clinical potential of ion-channel modulators across several therapeutic fields, especially in developing new strategies for treatment of ion channel-related diseases. The aim of this review is to overview the latest updates in the domain of peptide neurotoxins that affect voltage-gated calcium channels, with a special focus on ω-agatoxins.
Keywords: w-agatoxin IV B; peptide neurotoxins; voltage-gated calcium channels w-agatoxin IV B; peptide neurotoxins; voltage-gated calcium channels
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pringos, E.; Vignes, M.; Martinez, J.; Rolland, V. Peptide Neurotoxins That Affect Voltage-Gated Calcium Channels: A Close-Up on ω-Agatoxins. Toxins 2011, 3, 17-42.

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