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Toxins 2010, 2(5), 1134-1147; doi:10.3390/toxins2051134
Review

Host-Toxin Interactions Involving EspC and Pet, Two Serine Protease Autotransporters of the Enterobacteriaceae

1,* , 1
 and 2
Received: 9 April 2010; in revised form: 6 May 2010 / Accepted: 12 May 2010 / Published: 14 May 2010
(This article belongs to the Special Issue Protein Toxins as Proteases)
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Abstract: EspC and Pet are toxins secreted by the diarrheagenic enteropathogenic and enteroaggregative Escherichia coli pathotypes, respectively. Both toxins have a molecular mass around 110 kDa and belong to the same protein family called Serine Protease Autotransporters of the Enterobacteriaceae (SPATE). Furthermore, both toxins act within the cytosol of intoxicated epithelial cells to disrupt the architecture of the actin cytoskeleton. This cytopathic and enterotoxic effect results from toxin cleavage of the actin-binding protein fodrin, although the two toxins recognize different cleavage sites on fodrin. EspC and Pet also have dramatically different mechanisms of entering the target cell which appear dependent upon the E. coli pathotype. In this review, we compare/contrast EspC and Pet in regards to their mode of delivery into the target cell, their effects on fodrin and the actin cytoskeleton, and their possible effects on the physiology of the intestinal epithelial cell.
Keywords: enterotoxins; autotransporter proteins; actin cytoskeleton; diarrheagenic E. coli; serine proteases enterotoxins; autotransporter proteins; actin cytoskeleton; diarrheagenic E. coli; serine proteases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Navarro-Garcia, F.; Sonnested, M.; Teter, K. Host-Toxin Interactions Involving EspC and Pet, Two Serine Protease Autotransporters of the Enterobacteriaceae. Toxins 2010, 2, 1134-1147.

AMA Style

Navarro-Garcia F, Sonnested M, Teter K. Host-Toxin Interactions Involving EspC and Pet, Two Serine Protease Autotransporters of the Enterobacteriaceae. Toxins. 2010; 2(5):1134-1147.

Chicago/Turabian Style

Navarro-Garcia, Fernando; Sonnested, Michael; Teter, Ken. 2010. "Host-Toxin Interactions Involving EspC and Pet, Two Serine Protease Autotransporters of the Enterobacteriaceae." Toxins 2, no. 5: 1134-1147.



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