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Toxins 2010, 2(5), 1038-1053; doi:10.3390/toxins2051038
Review

Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin

1
, 1,2
 and 1,*
Received: 2 April 2010; in revised form: 29 April 2010 / Accepted: 5 May 2010 / Published: 11 May 2010
(This article belongs to the Special Issue Protein Toxins as Proteases)
View Full-Text   |   Download PDF [247 KB, uploaded 11 May 2010]
Abstract: Anthrax is caused by the gram-positive bacterium Bacillus anthracis. The pathogenesis of this disease is dependent on the presence of two binary toxins, edema toxin (EdTx) and lethal toxin (LeTx). LeTx, the major virulence factor contributing to anthrax, contains the effector moiety lethal factor (LF), a zinc-dependent metalloprotease specific for targeting mitogen-activated protein kinase kinases. This review will focus on the protease-specific activity and function of LF, and will include a discussion on the implications and consequences of this activity, both in terms of anthrax disease, and how this activity can be exploited to gain insight into other pathologic conditions.
Keywords: anthrax; lethal factor; mitogen-activated protein kinase kinase; pathogenesis; metalloprotease; tumorigenesis; retinal neovascularization anthrax; lethal factor; mitogen-activated protein kinase kinase; pathogenesis; metalloprotease; tumorigenesis; retinal neovascularization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bromberg-White, J.; Lee, C.-S.; Duesbery, N. Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin. Toxins 2010, 2, 1038-1053.

AMA Style

Bromberg-White J, Lee C-S, Duesbery N. Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin. Toxins. 2010; 2(5):1038-1053.

Chicago/Turabian Style

Bromberg-White, Jennifer; Lee, Chih-Shia; Duesbery, Nicholas. 2010. "Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin." Toxins 2, no. 5: 1038-1053.



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