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Toxins 2010, 2(4), 453-460; doi:10.3390/toxins2040453

Effects of Aflatoxin B1 and Fumonisin B1 on Blood Biochemical Parameters in Broilers

Center for Advanced Technological Research on Poultry, Biological Institute, Descalvado, SP, Brazil
Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil
Department of Animal Science, University of Missouri, Columbia, Missouri, USA
Veterinary Medical Diagnostic Laboratory, College Veterinary Medicine, University of Missouri, Columbia, Missouri, USA
Author to whom correspondence should be addressed.
Received: 4 March 2010 / Revised: 16 March 2010 / Accepted: 26 March 2010 / Published: 29 March 2010
(This article belongs to the Special Issue Feature Papers)
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The individual and combined effects of dietary aflatoxin B1 (AFB1) and fumonisin B1 (FB1) on liver pathology, serum levels of aspartate amino-transferase (AST) and plasma total protein (TP) of broilers were evaluated from 8 to 41 days of age. Dietary treatments included a 3 × 3 factorial arrangement with three levels of AFB1 (0, 50 and 200 μg AFB1/kg), and three levels of FB1 (0, 50 and 200 mg FB1/kg). At 33 days post feeding, with the exception of birds fed 50 mg FB1 only, concentrations of AST were higher (p < 0.05) in all other treatment groups when compared with controls. Plasma TP was lower (p < 0.05) at six days post feeding in groups fed 200 mgAFB1/kg alone or in combination with FB1. At day 33 days post feeding, with the exception of birds fed the highest combination of AFB1 and FB1 which had higher plasma TP than control birds, plasma TP of birds fed other dietary treatments were similar to controls. Broilers receiving the highest levels of AFB1 and FB1 had bile duct proliferation and trabecular disorder in liver samples. AFB1 singly or in combination with FB at the levels studied, caused liver damage and an increase in serum levels of AST. View Full-Text
Keywords: AFB1; FB1; broiler chickens; toxic effects AFB1; FB1; broiler chickens; toxic effects

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Tessari, E.N.C.; Kobashigawa, E.; Cardoso, A.L.S.P.; Ledoux, D.R.; Rottinghaus, G.E.; Oliveira, C.A.F. Effects of Aflatoxin B1 and Fumonisin B1 on Blood Biochemical Parameters in Broilers. Toxins 2010, 2, 453-460.

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