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Toxins 2010, 2(4), 428-452; doi:10.3390/toxins2040428

Toxins–Useful Biochemical Tools for Leukocyte Research

*  and
Department of Dermatology, Medical School Jena, Erfurter Strasse 35, 07740, Jena, Germany
* Author to whom correspondence should be addressed.
Received: 8 March 2010 / Accepted: 24 March 2010 / Published: 26 March 2010
(This article belongs to the collection Toxicity and Therapeutic Interventions in the Immune System)
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Leukocytes are a heterogeneous group of cells that display differences in anatomic localization, cell surface phenotype, and function. The different subtypes include e.g., granulocytes, monocytes, dendritic cells, T cells, B cells and NK cells. These different cell types represent the cellular component of innate and adaptive immunity. Using certain toxins such as pertussis toxin, cholera toxin or clostridium difficile toxin, the regulatory functions of Gαi, Gαs and small GTPases of the Rho family in leukocytes have been reported. A summary of these reports is discussed in this review.
Keywords: toxins; leukocytes; signal transduction toxins; leukocytes; signal transduction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cubillos, S.; Norgauer, J.; Lehmann, K. Toxins–Useful Biochemical Tools for Leukocyte Research. Toxins 2010, 2, 428-452.

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