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Toxins–Useful Biochemical Tools for Leukocyte Research
Department of Dermatology, Medical School Jena, Erfurter Strasse 35, 07740, Jena, Germany
* Author to whom correspondence should be addressed.
Received: 8 March 2010; Accepted: 24 March 2010 / Published: 26 March 2010
Abstract: Leukocytes are a heterogeneous group of cells that display differences in anatomic localization, cell surface phenotype, and function. The different subtypes include e.g., granulocytes, monocytes, dendritic cells, T cells, B cells and NK cells. These different cell types represent the cellular component of innate and adaptive immunity. Using certain toxins such as pertussis toxin, cholera toxin or clostridium difficile toxin, the regulatory functions of Gαi, Gαs and small GTPases of the Rho family in leukocytes have been reported. A summary of these reports is discussed in this review.
Keywords: toxins; leukocytes; signal transduction
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Cubillos, S.; Norgauer, J.; Lehmann, K. Toxins–Useful Biochemical Tools for Leukocyte Research. Toxins 2010, 2, 428-452.
Cubillos S, Norgauer J, Lehmann K. Toxins–Useful Biochemical Tools for Leukocyte Research. Toxins. 2010; 2(4):428-452.
Cubillos, Susana; Norgauer, Johannes; Lehmann, Katja. 2010. "Toxins–Useful Biochemical Tools for Leukocyte Research." Toxins 2, no. 4: 428-452.