Toxins–Useful Biochemical Tools for Leukocyte Research

doi:10.3390/toxins2040428

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Toxins 2010, 2(4), 428-452; doi:10.3390/toxins2040428

Review

Toxins–Useful Biochemical Tools for Leukocyte Research

Susana Cubillos, Johannes Norgauer* and Katja Lehmann

Department of Dermatology, Medical School Jena, Erfurter Strasse 35, 07740, Jena, Germany

* Author to whom correspondence should be addressed.

Received: 8 March 2010 / Accepted: 24 March 2010 / Published: 26 March 2010

(This article belongs to the Special Issue Toxicity and Therapeutic Interventions in the Immune System)

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Abstract: Leukocytes are a heterogeneous group of cells that display differences in anatomic localization, cell surface phenotype, and function. The different subtypes include e.g., granulocytes, monocytes, dendritic cells, T cells, B cells and NK cells. These different cell types represent the cellular component of innate and adaptive immunity. Using certain toxins such as pertussis toxin, cholera toxin or clostridium difficile toxin, the regulatory functions of Gα_i, Gαs and small GTPases of the Rho family in leukocytes have been reported. A summary of these reports is discussed in this review.

Keywords: toxins; leukocytes; signal transduction

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Cite This Article

MDPI and ACS Style

Cubillos, S.; Norgauer, J.; Lehmann, K. Toxins–Useful Biochemical Tools for Leukocyte Research. Toxins 2010, 2, 428-452.

AMA Style

Cubillos S, Norgauer J, Lehmann K. Toxins–Useful Biochemical Tools for Leukocyte Research. Toxins. 2010; 2(4):428-452.

Chicago/Turabian Style

Cubillos, Susana; Norgauer, Johannes; Lehmann, Katja. 2010. "Toxins–Useful Biochemical Tools for Leukocyte Research." Toxins 2, no. 4: 428-452.

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