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• Tessari, E
• Kobashigawa, E
• Cardoso, A
• Ledoux, D
• Rottinghaus, G
• Oliveira, C
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• Tessari, E
• Kobashigawa, E
• Cardoso, A
• Ledoux, D
• Rottinghaus, G
• Oliveira, C
• [+] on PubMed
• Tessari, E
• Kobashigawa, E
• Cardoso, A
• Ledoux, D
• Rottinghaus, G
• Oliveira, C

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Toxins 2010, 2(4), 453-460; doi:10.3390/toxins2040453

Article

Effects of Aflatoxin B₁ and Fumonisin B₁ on Blood Biochemical Parameters in Broilers

Eliana N. C. Tessari ¹ , Estela Kobashigawa ² , Ana Lúcia S. P. Cardoso ¹ , David R. Ledoux ³ , George E. Rottinghaus ⁴  and Carlos A. F. Oliveira ^2,*

¹ Center for Advanced Technological Research on Poultry, Biological Institute, Descalvado, SP, Brazil ² Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil ³ Department of Animal Science, University of Missouri, Columbia, Missouri, USA ⁴ Veterinary Medical Diagnostic Laboratory, College Veterinary Medicine, University of Missouri, Columbia, Missouri, USA

* Author to whom correspondence should be addressed.

Received: 4 March 2010; in revised form: 16 March 2010 / Accepted: 26 March 2010 / Published: 29 March 2010

(This article belongs to the Special Issue Feature Papers)

Download PDF Full-Text [274 KB, uploaded 29 March 2010 10:27 CEST]

Abstract: The individual and combined effects of dietary aflatoxin B₁ (AFB₁) and fumonisin B₁ (FB₁) on liver pathology, serum levels of aspartate amino-transferase (AST) and plasma total protein (TP) of broilers were evaluated from 8 to 41 days of age. Dietary treatments included a 3 × 3 factorial arrangement with three levels of AFB₁ (0, 50 and 200 μg AFB₁/kg), and three levels of FB₁ (0, 50 and 200 mg FB₁/kg). At 33 days post feeding, with the exception of birds fed 50 mg FB₁ only, concentrations of AST were higher (p < 0.05) in all other treatment groups when compared with controls. Plasma TP was lower (p < 0.05) at six days post feeding in groups fed 200 mgAFB₁/kg alone or in combination with FB₁. At day 33 days post feeding, with the exception of birds fed the highest combination of AFB₁ and FB₁ which had higher plasma TP than control birds_, plasma TP of birds fed other dietary treatments were similar to controls. Broilers receiving the highest levels of AFB₁ and FB₁ had bile duct proliferation and trabecular disorder in liver samples. AFB₁ singly or in combination with FB at the levels studied, caused liver damage and an increase in serum levels of AST.

Keywords: AFB₁; FB₁; broiler chickens; toxic effects

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