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Toxins 2010, 2(4), 856-877; doi:10.3390/toxins2040856

The Double-Edged Sword of Autoimmunity: Lessons from Multiple Sclerosis

Institute of Immunology, Faculty of Medicine, University of Oslo, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway
Received: 14 April 2010 / Accepted: 21 April 2010 / Published: 22 April 2010
(This article belongs to the collection Toxicity and Therapeutic Interventions in the Immune System)
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The relationship between immune responses to self-antigens and autoimmune disease is unclear. In contrast to its animal model experimental autoimmune encephalomyelitis (EAE), which is driven by T cell responses to myelin antigens, the target antigen of the intrathecal immune response in multiple sclerosis (MS) has not been identified. Although the immune response in MS contributes significantly to tissue destruction, the action of immunocompetent cells within the central nervous system (CNS) may also hold therapeutic potential. Thus, treatment of MS patients with glatiramer acetate triggers a protective immune response. Here we review the immunopathogenesis of MS and some recent findings on the mechanism of glatiramer acetate (GA).
Keywords: autoimmunity; multiple sclerosis; T cells; B cells; glatiramer acetate autoimmunity; multiple sclerosis; T cells; B cells; glatiramer acetate
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hestvik, A.L.K. The Double-Edged Sword of Autoimmunity: Lessons from Multiple Sclerosis. Toxins 2010, 2, 856-877.

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