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Toxins 2018, 10(7), 272; https://doi.org/10.3390/toxins10070272

Mycotoxin Biosensor Based on Optical Planar Waveguide

1
Materials & Engineering Research Institute, Sheffield Hallam University, Sheffield S1 1WB, UK
2
Department of Physics, Faculty of Science, The University of Kufa, Najaf 54001, Iraq
3
Department of Chemistry, The University of Sheffield, Sheffield S3 7HF, UK
4
Agro-Environmental Research Institute, NARIC, Gödöllő 2100, Hungary
*
Author to whom correspondence should be addressed.
Received: 19 April 2018 / Revised: 6 June 2018 / Accepted: 25 June 2018 / Published: 3 July 2018
(This article belongs to the Special Issue Advanced Sensors for Toxins)
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Abstract

The research aim of this work is to develop a simple and highly sensitive optical biosensor for detection of mycotoxins. This sensor is built on a planar waveguide operating on the polarization interferometry principle, i.e., detecting a phase shift between p- and s-components of polarized light developed during the binding of analyte molecules. The operation of the proposed sensor is similar to that of a Mach–Zehnder interferometer, while its design is much simpler and it does not require splitting the waveguide into two arms. The refractive index sensitivity of the polarization interferometer sensor was in the range of 5200 radians per refractive index unit (RIU). Several tests were conducted to detect ochratoxin A (OTA) at different concentrations in direct immunoassay with specific antibodies immobilized in the sensing window. The lowest concentration of OTA of 0.01 ng/mL caused a phase shift of nearly one period. The results obtained prove high sensitivity of the sensors, which are capable of detecting even lower concentrations of mycotoxins at the ppt (part-per-trillion) level. View Full-Text
Keywords: optical biosensor; planar waveguide; polarization interferometer; refractive index sensitivity; mycotoxins optical biosensor; planar waveguide; polarization interferometer; refractive index sensitivity; mycotoxins
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Al-Jawdah, A.; Nabok, A.; Jarrah, R.; Holloway, A.; Tsargorodska, A.; Takacs, E.; Szekacs, A. Mycotoxin Biosensor Based on Optical Planar Waveguide. Toxins 2018, 10, 272.

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