Toxins 2009, 1(2), 59-73; doi:10.3390/toxins1020059
Article

Immune Response to Chlamydophila abortus POMP91B Protein in the Context of Different Pathogen Associated Molecular Patterns (PAMP); Role of Antigen in the Orientation of Immune Response

Vincent Le Moigneemail, Georges Robreauemail and Wahib Mahana* email
Unversité de Bretagne Occidentale (UBO), IUT de Quimper, 2, rue de l’Université, 29334 Quimper, France
* Author to whom correspondence should be addressed.
Received: 7 September 2009; in revised form: 30 September 2009 / Accepted: 10 October 2009 / Published: 13 October 2009
(This article belongs to the Special Issue Toxicity and Therapeutic Interventions in the Immune System)
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Abstract: In a previous study, we used bacterial flagellin to deliver antigens such as p27 of Mycobacterium tuberculosis to a host immune system and obtained a potent Th1 responsecompared to those obtained with Freund’s adjuvant and DNA immunization. In the current study, using a POMP91B antigen of Chlamydophila abortus, a human and animal pathogen, as a model, we found that this antigen is unable to promote Th1 response. However, this antigen, unlike others, was able to induce a good Th2 response and IL-4 production after immunization by recombinant protein in Freund’s adjuvant or in phosphate buffered saline. Our results suggest that immune response is not only dependent on the immunization adjuvant, but also dependent on the nature of antigen used.
Keywords: POMP91B; PAMP; flagellin; immune response; adjuvant

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MDPI and ACS Style

Le Moigne, V.; Robreau, G.; Mahana, W. Immune Response to Chlamydophila abortus POMP91B Protein in the Context of Different Pathogen Associated Molecular Patterns (PAMP); Role of Antigen in the Orientation of Immune Response. Toxins 2009, 1, 59-73.

AMA Style

Le Moigne V, Robreau G, Mahana W. Immune Response to Chlamydophila abortus POMP91B Protein in the Context of Different Pathogen Associated Molecular Patterns (PAMP); Role of Antigen in the Orientation of Immune Response. Toxins. 2009; 1(2):59-73.

Chicago/Turabian Style

Le Moigne, Vincent; Robreau, Georges; Mahana, Wahib. 2009. "Immune Response to Chlamydophila abortus POMP91B Protein in the Context of Different Pathogen Associated Molecular Patterns (PAMP); Role of Antigen in the Orientation of Immune Response." Toxins 1, no. 2: 59-73.

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