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Toxins 2010, 2(1), 54-68; doi:10.3390/toxins2010054
Review

Reciprocal Interactions between Lactoferrin and Bacterial Endotoxins and Their Role in the Regulation of the Immune Response

1, 1, 2 and 1,*
Received: 1 December 2009; in revised form: 23 December 2009 / Accepted: 25 December 2009 / Published: 8 January 2010
(This article belongs to the collection Toxicity and Therapeutic Interventions in the Immune System)
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Abstract: Lactoferrin (Lf), an iron-binding glycoprotein expressed in most biological fluids, represents a major component of the mammalian innate immune system. Lf’s multiple activities rely not only on its capacity to bind iron, but also to interact with molecular and cellular components of both host and pathogens. Lf can bind and sequester lipopolysaccharide (LPS), thus preventing pro-inflammatory pathway activation, sepsis and tissue damage. However, Lf-bound LPS may retain the capacity to induce cell activation via Toll-like receptor 4-dependent and -independent mechanisms. This review discusses the complex interplay between Lf and LPS and its relevance in the regulation of the immune response.
Keywords: lactoferrin; lipopolysaccharide; inflammation; immune response lactoferrin; lipopolysaccharide; inflammation; immune response
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Latorre, D.; Puddu, P.; Valenti, P.; Gessani, S. Reciprocal Interactions between Lactoferrin and Bacterial Endotoxins and Their Role in the Regulation of the Immune Response. Toxins 2010, 2, 54-68.

AMA Style

Latorre D, Puddu P, Valenti P, Gessani S. Reciprocal Interactions between Lactoferrin and Bacterial Endotoxins and Their Role in the Regulation of the Immune Response. Toxins. 2010; 2(1):54-68.

Chicago/Turabian Style

Latorre, Daniela; Puddu, Patrizia; Valenti, Piera; Gessani, Sandra. 2010. "Reciprocal Interactions between Lactoferrin and Bacterial Endotoxins and Their Role in the Regulation of the Immune Response." Toxins 2, no. 1: 54-68.


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