Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost
Abstract
:1. Introduction
2. Methods
2.1. Randomization and Interventions
2.2. Symptoms and Data Evaluation
2.3. Outcome Measures
2.4. Sample Size
2.5. Data Analysis
3. Results
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
Abbreviations
DCs | Dendritic cells |
GALT | Gut associated lymphoid tissue |
NICU | Neonatal intensive care unit |
CFU | Colony forming unit |
IL | Interleukin |
References
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Total n = 60 | L. reuteri DSM 17938 (n = 30) | Placebo (n = 30) | p |
---|---|---|---|
Gestational age | 30.2 ± 1.2 | 30.1 ± 1.2 | n.s. |
Gender (M/F) | 15/15 | 16/14 | n.s. |
Delivery (VD/CD) | 4/26 | 5/25 | n.s. |
Birth weight (g) | 1471.5 ± 455.1 | 1406.6 ± 536.4 | n.s. |
Clinical Parameter | L. reuteri DSM 17938 | Placebo | p |
---|---|---|---|
Time taken to reach full enteral feeding (day) | 4.2 ± 1.1 | 7.5 ± 3.2 | <0.01 |
Day of hospitalization (day) | 13.4 ± 2.2 | 22.4 ± 3.2 | <0.01 |
Duration of antibiotic treatment (day) | 4.2 ± 4.3 | 12.5 ± 7.2 | <0.01 |
Time to regain birth weight (day) | 6.4 ± 1.6 | 7.3 ± 1.3 | <0.05 |
Weight at the end of the study (g) | 1955.3 ± 653.4 | 1737.6 ± 512 | <0.05 |
Stool frequency (n/day on the last week) | 2.5 ± 0.7 | 2.8 ± 0.9 | <0.05 |
Group | IL-1β | IL-8 | IL-10 | IL-17 | Calprotectin | TNFα | IL-6 |
---|---|---|---|---|---|---|---|
pg/mL | pg/mL | pg/mL | pg/mL | μg/g | pg/mL | pg/mL | |
LR | 57.4 ± 73.3 | 56.7 ± 72.4 | 6.3 ± 3.2 | 6.5 ± 1.9 | 246.6 ± 78.4 | 8.0 ± 3.1 | 3.2 ± 2.8 |
Placebo | 17.1 ± 16.7 | 197.3 ± 222.1 | 4.2 ± 1.7 | 8.8 ± 3.5 | 323.9 ± 111.7 | 12.7 ± 7.7 | 2.9 ± 1.7 |
p | 0.04 | 0.04 | 0.02 | 0.02 | 0.01 | 0.01 | n.s. |
Parameter | L. reuteri DSM 17938 | Placebo | p |
---|---|---|---|
T1/2 (Half-emptying time) (min) | 73.8 ± 7.5 | 80.4. ± 6.1 | 0.0004 |
Fasting antral area (cm2) | 0.6 ± 0.2 | 0.8 ± 0.3 | 0.009 |
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Indrio, F.; Riezzo, G.; Tafuri, S.; Ficarella, M.; Carlucci, B.; Bisceglia, M.; Polimeno, L.; Francavilla, R. Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost. Nutrients 2017, 9, 965. https://doi.org/10.3390/nu9090965
Indrio F, Riezzo G, Tafuri S, Ficarella M, Carlucci B, Bisceglia M, Polimeno L, Francavilla R. Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost. Nutrients. 2017; 9(9):965. https://doi.org/10.3390/nu9090965
Chicago/Turabian StyleIndrio, Flavia, Giuseppe Riezzo, Silvio Tafuri, Maria Ficarella, Barbara Carlucci, Massimo Bisceglia, Lorenzo Polimeno, and Ruggiero Francavilla. 2017. "Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost" Nutrients 9, no. 9: 965. https://doi.org/10.3390/nu9090965