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Nutrients 2017, 9(8), 853; doi:10.3390/nu9080853

Association and Interaction Effect of AGTR1 and AGTR2 Gene Polymorphisms with Dietary Pattern on Metabolic Risk Factors of Cardiovascular Disease in Malaysian Adults

1
School of Biosciences, Taylor’s University, 47500 Subang Jaya, Malaysia
2
Graduate School of Human Health Science, University of Nagasaki, Nagayo-cho, Nagasaki 851-2195, Japan
3
Faculty of Applied Sciences, UCSI University, Taman Connaught, 56000 Kuala Lumpur, Malaysia
*
Author to whom correspondence should be addressed.
Received: 26 May 2017 / Revised: 25 July 2017 / Accepted: 7 August 2017 / Published: 9 August 2017
(This article belongs to the Special Issue Selected Papers from APNNO Biennial Conference 2016)
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Abstract

Gene-diet interaction using a multifactorial approach is preferred to study the multiple risk factors of cardiovascular disease (CVD). This study examined the association and gene-diet interaction effects of the angiotensin II type 1 receptor (AGTR1) gene (rs5186), and type 2 receptor (AGTR2) gene (rs1403543) polymorphisms on metabolic risk factors of CVD in Malaysian adults. CVD parameters (BMI, blood pressure, glycated hemoglobin, total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), and TC/HDL-C ratio), and constructed dietary patterns “vegetables, fruits, and soy diet” (VFSD), and “rice, egg, and fish diet” (REFD) were obtained from previous studies. Genotyping analysis was performed by real-time PCR using Taqman probes. The subjects were 507 adults (151 Malays; 179 Chinese; and 177 Indians). Significant genetic associations were obtained on blood lipids for rs5186 in Malays and Chinese, and rs1403543 in Chinese females. The significant gene-diet interaction effects after adjusting for potential confounders were: rs5186 × VFSD on blood pressure in Malays (p = 0.016), and in Chinese on blood lipids for rs5186 × REFD (p = 0.009–0.023), and rs1403543 × VFSD in female subjects (p = 0.001–0.011). Malays and Chinese showed higher risk for blood pressure and/or lipids involving rs5186 and rs1403543 SNPs together with gene-diet interactions, but not Indians. View Full-Text
Keywords: gene-diet interaction; AGTR1; AGTR2; rs5186; rs1403543; blood lipids; blood pressure; Malaysian adults gene-diet interaction; AGTR1; AGTR2; rs5186; rs1403543; blood lipids; blood pressure; Malaysian adults
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yap, R.W.K.; Shidoji, Y.; Yap, W.S.; Masaki, M. Association and Interaction Effect of AGTR1 and AGTR2 Gene Polymorphisms with Dietary Pattern on Metabolic Risk Factors of Cardiovascular Disease in Malaysian Adults. Nutrients 2017, 9, 853.

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