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Nutrients 2017, 9(8), 803; doi:10.3390/nu9080803 (registering DOI)

Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men

Department of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of Physical Education, 40-065 Katowice, Poland
Department of Tourism and Health Promotion, University of Technology, Faculty of Physical Education and Physiotherapy, 45-758 Opole, Poland
Department of Biochemistry, Poznan University of Physical Education, 61-871 Poznań, Poland
Author to whom correspondence should be addressed.
Received: 11 May 2017 / Revised: 11 July 2017 / Accepted: 24 July 2017 / Published: 26 July 2017
(This article belongs to the Special Issue Dietary Supplements)
View Full-Text   |   Download PDF [777 KB, uploaded 26 July 2017]   |  


Extracts of Ginkgo biloba leaves, a natural source of flavonoids and polyphenolic compounds, are commonly used as therapeutic agents for the improvement of both cognitive and physiological performance. The present study was aimed to test the effects of a six-week supplementation with 160 mg/day of a standardized extract of Ginkgo biloba or a matching placebo on aerobic performance, blood antioxidant capacity, and brain-derived neurotrophic factor (BDNF) level in healthy, physically active young men, randomly allocated to two groups (n = 9 each). At baseline, as well as on the day following the treatment, the participants performed an incremental cycling test for the assessment of maximal oxygen uptake. Venous blood samples taken at rest, then immediately post-test and following 1 h of recovery, were analyzed for activities of antioxidant enzymes and plasma concentrations of non-enzymatic antioxidants, total phenolics, uric acid, lipid peroxidation products, ferric reducing ability of plasma (FRAP), and serum brain-derived neurotrophic factor (BDNF). Our results show that six weeks’ supplementation with Ginkgo biloba extract in physically active young men may provide some marginal improvements in their endurance performance expressed as VO2max and blood antioxidant capacity, as evidenced by specific biomarkers, and elicit somewhat better neuroprotection through increased exercise-induced production of BDNF. View Full-Text
Keywords: dietary supplements; Ginkgo biloba extract; antioxidant capacity; BDNF dietary supplements; Ginkgo biloba extract; antioxidant capacity; BDNF

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sadowska-Krępa, E.; Kłapcińska, B.; Pokora, I.; Domaszewski, P.; Kempa, K.; Podgórski, T. Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men. Nutrients 2017, 9, 803.

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