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Nutrients 2017, 9(7), 778; doi:10.3390/nu9070778

Food-Derived Antioxidant Polysaccharides and Their Pharmacological Potential in Neurodegenerative Diseases

1
Center for Bioresources & Drug Discovery and School of Biosciences & Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
2
School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 31 May 2017 / Revised: 10 July 2017 / Accepted: 13 July 2017 / Published: 19 July 2017
(This article belongs to the Special Issue Antioxidants in Health and Disease)
View Full-Text   |   Download PDF [881 KB, uploaded 19 July 2017]   |  

Abstract

Oxidative stress is known to impair architecture and function of cells, which may lead to various chronic diseases, and therefore therapeutic and nutritional interventions to reduce oxidative damages represent a viable strategy in the amelioration of oxidative stress-related disorders, including neurodegenerative diseases. Over the past decade, a variety of natural polysaccharides from functional and medicinal foods have attracted great interest due to their antioxidant functions such as scavenging free radicals and reducing oxidative damages. Interestingly, these antioxidant polysaccharides are also found to attenuate neuronal damages and alleviate cognitive and motor decline in a range of neurodegenerative models. It has recently been established that the neuroprotective mechanisms of polysaccharides are related to oxidative stress-related pathways, including mitochondrial function, antioxidant defense system and pathogenic protein aggregation. Here, we first summarize the current status of antioxidant function of food-derived polysaccharides and then attempt to appraise their anti-neurodegeneration activities. View Full-Text
Keywords: polysaccharide; antioxidant; oxidative stress; inflammatory stress; proteotoxic stress; neurodegeneration polysaccharide; antioxidant; oxidative stress; inflammatory stress; proteotoxic stress; neurodegeneration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, H.; Ding, F.; Xiao, L.; Shi, R.; Wang, H.; Han, W.; Huang, Z. Food-Derived Antioxidant Polysaccharides and Their Pharmacological Potential in Neurodegenerative Diseases. Nutrients 2017, 9, 778.

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