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Nutrients 2017, 9(7), 774; doi:10.3390/nu9070774

The Combined Intervention with Germinated Vigna radiata and Aerobic Interval Training Protocol Is an Effective Strategy for the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) and Other Alterations Related to the Metabolic Syndrome in Zucker Rats

1
Department of Physiology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, Institute of Health and Sport, University of Granada, 18071 Granada, Spain
2
Department of Histology, Institute of Neurosciences, Centre for Biomedical Research, University of Granada, 18071 Granada, Spain
3
Centro de Instrumentación Científica, University of Granada, Campus Universitario de Fuentenueva s/n, 18071 Granada, Spain
4
Department of Pharmacology, School of Pharmacy, University of Granada, Campus Universitario de Cartuja s/n, 18071 Granada, Spain
*
Author to whom correspondence should be addressed.
Received: 24 April 2017 / Revised: 14 July 2017 / Accepted: 14 July 2017 / Published: 19 July 2017
(This article belongs to the Special Issue Nutrition and Non-alcoholic Fatty Liver Disease)
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Abstract

Metabolic syndrome (MetS) is a group of related metabolic alterations that increase the risk of developing non-alcoholic fatty liver disease (NAFLD). Several lifestyle interventions based on dietary treatment with functional ingredients and physical activity are being studied as alternative or reinforcement treatments to the pharmacological ones actually in use. In the present experiment, the combined treatment with mung bean (Vigna radiata), a widely used legume with promising nutritional and health benefits that was included in the experimental diet as raw or 4 day-germinated seed flour, and aerobic interval training protocol (65–85% VO2 max) has been tested in lean and obese Zucker rats following a 2 × 2 × 2 (2 phenotypes, 2 dietary interventions, 2 lifestyles) factorial ANOVA (Analysis of Variance) statistical analysis. Germination of V. radiata over a period of four days originated a significant protein hydrolysis leading to the appearance of low molecular weight peptides. The combination of 4 day-germinated V. radiata and aerobic interval training was more efficient compared to raw V. radiata at improving the aerobic capacity and physical performance, hepatic histology and functionality, and plasma lipid parameters as well as reverting the insulin resistance characteristic of the obese Zucker rat model. In conclusion, the joint intervention with legume sprouts and aerobic interval training protocol is an efficient treatment to improve the alterations of glucose and lipid metabolism as well as hepatic histology and functionality related to the development of NAFLD and the MetS. View Full-Text
Keywords: non-alcoholic fatty liver disease; metabolic syndrome; Vigna radiata; legume protein hydrolyzate; aerobic interval training; diet; germination; obesity; exercise; liver histology non-alcoholic fatty liver disease; metabolic syndrome; Vigna radiata; legume protein hydrolyzate; aerobic interval training; diet; germination; obesity; exercise; liver histology
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Kapravelou, G.; Martínez, R.; Nebot, E.; López-Jurado, M.; Aranda, P.; Arrebola, F.; Cantarero, S.; Galisteo, M.; Porres, J.M. The Combined Intervention with Germinated Vigna radiata and Aerobic Interval Training Protocol Is an Effective Strategy for the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) and Other Alterations Related to the Metabolic Syndrome in Zucker Rats. Nutrients 2017, 9, 774.

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