Next Article in Journal
Test-Retest Reliability and Convergent Validity of Two Brief Fruit and Vegetable Intake Questionnaires among School-Aged Children
Next Article in Special Issue
Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention
Previous Article in Journal
Adherence to a Gluten Free Diet Is Associated with Receiving Gluten Free Foods on Prescription and Understanding Food Labelling
Previous Article in Special Issue
Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Nutrients 2017, 9(7), 706; doi:10.3390/nu9070706

Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure

1
National Institute of Gastroenterology “S. de Bellis”, Institute of Research, Via Turi, 27, 70013 Castellana Grotte, Italy
2
Institute of Sciences of Food Production C.N.R., Unit of Lecce, via Monteroni, 73100 Lecce, Italy
3
Department of Pharmacy, School of Pharmacy, University of Salerno, 84084 Fisciano, Italy
4
University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
5
European Biomedical Research Institute of Salerno (EBRIS), Via S. de Renzi, 3, 84125 Salerno, Italy
*
Authors to whom correspondence should be addressed.
Received: 21 April 2017 / Revised: 29 June 2017 / Accepted: 4 July 2017 / Published: 6 July 2017
(This article belongs to the Special Issue Nutrients, Infectious and Inflammatory Diseases)
View Full-Text   |   Download PDF [2054 KB, uploaded 6 July 2017]   |  

Abstract

Dendritic cells’ (DCs) ability to present antigens and initiate the adaptive immune response confers them a pivotal role in immunological defense against hostile infection and, at the same time, immunological tolerance towards harmless components of the microbiota. Food products can modulate the inflammatory status of intestinal DCs. Among nutritionally-derived products, we investigated the ability of quercetin to suppress inflammatory cytokines secretion, antigen presentation, and DCs migration towards the draining lymph nodes. We recently identified the Slpi expression as a crucial checkpoint required for the quercetin-induced inflammatory suppression. Here we demonstrate that Slpi-KO DCs secrete a unique panel of cytokines and chemokines following quercetin exposure. In vivo, quercetin-enriched food is able to induce Slpi expression in the ileum, while little effects are detectable in the duodenum. Furthermore, Slpi expressing cells are more frequent at the tip compared to the base of the intestinal villi, suggesting that quercetin exposure could be more efficient for DCs projecting periscopes in the intestinal lumen. These data suggest that quercetin-enriched nutritional regimes may be efficient for suppressing inflammatory syndromes affecting the ileo-colonic tract. View Full-Text
Keywords: quercetin; dendritic cells; Slpi; inflammation quercetin; dendritic cells; Slpi; inflammation
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

De Santis, S.; Galleggiante, V.; Scandiffio, L.; Liso, M.; Sommella, E.; Sobolewski, A.; Spilotro, V.; Pinto, A.; Campiglia, P.; Serino, G.; Santino, A.; Notarnicola, M.; Chieppa, M. Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure. Nutrients 2017, 9, 706.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top