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Nutrients 2017, 9(10), 1077; doi:10.3390/nu9101077

Translational Aspects of Diet and Non-Alcoholic Fatty Liver Disease

1
Division of Gastroenterology and Hepatology, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland
2
Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland
*
Author to whom correspondence should be addressed.
Received: 5 July 2017 / Revised: 25 September 2017 / Accepted: 26 September 2017 / Published: 28 September 2017
(This article belongs to the Special Issue Nutrition and Non-alcoholic Fatty Liver Disease)
View Full-Text   |   Download PDF [235 KB, uploaded 28 September 2017]

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases ranging from simple steatosis without inflammation or fibrosis to nonalcoholic steatohepatitis (NASH). Despite the strong association between dietary factors and NAFLD, no dietary animal model of NAFLD fully recapitulates the complex metabolic and histological phenotype of the disease, although recent models show promise. Although animal models have significantly contributed to our understanding of human diseases, they have been less successful in accurate translation to predict effective treatment strategies. We discuss strategies to overcome this challenge, in particular the adoption of big data approaches combining clinical phenotype, genomic heterogeneity, transcriptomics, and metabolomics changes to identify the ideal NAFLD animal model for a given scientific question or to test a given drug. We conclude by noting that novel big data approaches may help to bridge the translational gap for selecting dietary models of NAFLD. View Full-Text
Keywords: NAFLD; NASH; diet; metabolic syndrome; insulin resistance NAFLD; NASH; diet; metabolic syndrome; insulin resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Goossens, N.; Jornayvaz, F.R. Translational Aspects of Diet and Non-Alcoholic Fatty Liver Disease. Nutrients 2017, 9, 1077.

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