Next Article in Journal
Dietary Components and Metabolic Dysfunction: Translating Preclinical Studies into Clinical Practice
Previous Article in Journal
A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis
Article Menu

Export Article

Open AccessArticle
Nutrients 2016, 8(10), 631; doi:10.3390/nu8100631

Plasma 25-Hydroxyvitamin D Is Related to Protein Signaling Involved in Glucose Homeostasis in a Tissue-Specific Manner

1
Clinical Exercise Science Research Program, Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne VIC 8001, Australia
2
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, MHRP, 43-51 Kanooka Grove, Clayton VIC 3168, Australia
3
Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Waurn Ponds VIC 3217, Australia
4
Diabetes and Vascular Medicine Unit, Monash Health, Locked Bag 29, Clayton VIC 3168, Australia
*
Author to whom correspondence should be addressed.
Received: 1 September 2016 / Revised: 25 September 2016 / Accepted: 3 October 2016 / Published: 13 October 2016
View Full-Text   |   Download PDF [1241 KB, uploaded 13 October 2016]   |  

Abstract

Vitamin D has been suggested to play a role in glucose metabolism. However, previous findings are contradictory and mechanistic pathways remain unclear. We examined the relationship between plasma 25-hydroxyvitamin D (25(OH)D), insulin sensitivity, and insulin signaling in skeletal muscle and adipose tissue. Seventeen healthy adults (Body mass index: 26 ± 4; Age: 30 ± 12 years) underwent a hyperinsulinemic-euglycemic clamp, and resting skeletal muscle and adipose tissue biopsies. In this cohort, the plasma 25(OH)D concentration was not associated with insulin sensitivity (r = 0.19, p = 0.56). However, higher plasma 25(OH)D concentrations correlated with lower phosphorylation of glycogen synthase kinase-3 (GSK-3) αSer21 and βSer9 in skeletal muscle (r = −0.66, p = 0.015 and r = −0.53, p = 0.06, respectively) and higher GSK-3 αSer21 and βSer9 phosphorylation in adipose tissue (r = 0.82, p < 0.01 and r = 0.62, p = 0.042, respectively). Furthermore, higher plasma 25(OH)D concentrations were associated with greater phosphorylation of both protein kinase-B (AktSer473) (r = 0.78, p < 0.001) and insulin receptor substrate-1 (IRS-1Ser312) (r = 0.71, p = 0.01) in adipose tissue. No associations were found between plasma 25(OH)D concentration and IRS-1Tyr612 phosphorylation in skeletal muscle and adipose tissue. The divergent findings between muscle and adipose tissue with regard to the association between 25(OH)D and insulin signaling proteins may suggest a tissue-specific interaction with varying effects on glucose homeostasis. Further research is required to elucidate the physiological relevance of 25(OH)D in each tissue. View Full-Text
Keywords: diabetes; glucose homeostasis; insulin resistance; insulin signaling; vitamin D; 25-hydroxyvitamin D diabetes; glucose homeostasis; insulin resistance; insulin signaling; vitamin D; 25-hydroxyvitamin D
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Parker, L.; Levinger, I.; Mousa, A.; Howlett, K.; de Courten, B. Plasma 25-Hydroxyvitamin D Is Related to Protein Signaling Involved in Glucose Homeostasis in a Tissue-Specific Manner. Nutrients 2016, 8, 631.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top