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Nutrients 2016, 8(10), 607; doi:10.3390/nu8100607

Hepatoprotective Effect of Opuntia robusta and Opuntia streptacantha Fruits against Acetaminophen-Induced Acute Liver Damage

1
Department of Physiology and Pharmacology, Basic Science Center, Universidad Autónomade Aguascalientes, Aguascalientes 20131, Mexico
2
Department of Morphology, Basic Science Center, Universidad Autónoma de Aguascalientes, Aguascalientes 20131, Mexico
3
Department of Physiology, University Center of Health Sciences, Universidad de Guadalajara, Guadalajara 44340, Mexico
4
Food Technology Unit, Secretary of Research and Graduate Studies, Universidad Autónoma de Nayarit, Tepic 63160, Mexico
5
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen 9713 GZ, The Netherlands
6
Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen 9713 GZ, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 4 July 2016 / Accepted: 20 September 2016 / Published: 4 October 2016
(This article belongs to the Special Issue Health-Promoting Components of Fruits and Vegetables in Human Health)
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Abstract

Acetaminophen (APAP)-induced acute liver failure (ALF) is a serious health problem in developed countries. N-acetyl-L-cysteine (NAC), the current therapy for APAP-induced ALF, is not always effective, and liver transplantation is often needed. Opuntia spp. fruits are an important source of nutrients and contain high levels of bioactive compounds, including antioxidants. The aim of this study was to evaluate the hepatoprotective effect of Opuntia robusta and Opuntia streptacantha extracts against APAP-induced ALF. In addition, we analyzed the antioxidant activities of these extracts. Fruit extracts (800mg/kg/day, orally) were given prophylactically to male Wistar rats before intoxication with APAP (500 mg/kg, intraperitoneally). Rat hepatocyte cultures were exposed to 20mmol/LAPAP, and necrosis was assessed by LDH leakage. Opuntia robusta had significantly higher levels of antioxidants than Opuntia streptacantha. Both extracts significantly attenuated APAP-induced injury markers AST, ALT and ALP and improved liver histology. The Opuntia extracts reversed APAP-induced depletion of liver GSH and glycogen stores. In cultured hepatocytes, Opuntia extracts significantly reduced leakage of LDH and cell necrosis, both prophylactically and therapeutically. Both extracts appeared to be superior to NAC when used therapeutically. We conclude that Opuntia extracts are hepatoprotective and can be used as a nutraceutical to prevent ALF. View Full-Text
Keywords: Opuntia fruits; acetaminophen; acute liver failure; antioxidants; hepatoprotective; nutraceutical Opuntia fruits; acetaminophen; acute liver failure; antioxidants; hepatoprotective; nutraceutical
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González-Ponce, H.A.; Martínez-Saldaña, M.C.; Rincón-Sánchez, A.R.; Sumaya-Martínez, M.T.; Buist-Homan, M.; Faber, K.N.; Moshage, H.; Jaramillo-Juárez, F. Hepatoprotective Effect of Opuntia robusta and Opuntia streptacantha Fruits against Acetaminophen-Induced Acute Liver Damage. Nutrients 2016, 8, 607.

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